Increase in multiple antibiotic resistance in nontyphoidal salmonellas from humans in England and Wales: a comparison of data for 1994 and 1996.
Increase in multiple antibiotic resistance in nontyphoidal salmonellas from humans in England and Wales: a comparison of data for 1994 and 1996.
复制标题
英格兰和威尔士人类非伤寒沙门氏菌对多种抗生素耐药性的增加：1994 年和 1996 年数据比较。
作者：
E. Threlfall;L. Ward;J. Skinner;B. Rowe
1996年英格兰和威尔士沙门氏菌对4种或4种以上抗菌药物的多重耐药性发生率与1994年的相应数据进行了比较。对于沙门氏菌的多重耐药性仍然很罕见，尽管高比例的噬菌体6A型分离株已显示出对氨苄青霉素的耐药性。对于鼠伤寒沙门氏鼠伤寒多重耐药性持续增加，81%的分离株现在具有多重耐药性。在S.鼠伤寒沙门氏菌一直是多重耐药DT 104的持续流行病，并且这种噬菌体类型的菌株对甲氧苄啶和/或环丙沙星具有额外耐药性的出现越来越多。对于鼠伤寒沙门氏virchow，多重耐药性增加10%主要集中在返回旅行者中常见的两种噬菌体类型。对于鼠伤寒沙门氏然而，多重耐药性的发生率大幅增加，现在有超过50%的菌株具有多重耐药性。多重耐药链球菌对环丙沙星耐药的发生率显著增加。鼠伤寒沙门氏菌DT 104、S. virchow和S.自1993年氟喹诺酮类抗生素恩诺沙星在英国被批准用于兽医用途以来，hadar特别令人担忧。
The incidence of multiple drug resistance (to four or more antimicrobials) in salmonellas from humans in England and Wales in 1996 has been compared with corresponding data for 1994. For Salmonella enteritidis multiple resistance has remained rare, although a high proportion of isolates of phage type 6A have shown resistance to ampicillin. For S. typhimurium multiple resistance has continued to increase, with 81% of isolates now multiresistant. Of particular importance in S. typhimurium has been the continued epidemic of multiresistant DT 104 and the increasing occurrence of strains of this phage type with additional resistance to trimethoprim and/or ciprofloxacin. For S. virchow, a 10% increase in multiple resistance is mainly concentrated in two phage types common in returning travellers. For S. hadar, there has been a substantial increase in the incidence of multiple resistance with over 50% of isolates now multiresistant. Substantial increases in the incidence of resistance to ciprofloxacin in multiresistant S. typhimurium DT 104, S. virchow, and S. hadar since 1993, when the fluoroquinolone antibiotic enrofloxacin was licensed for veterinary use in the UK, are of particular concern.