INHIBITION PATTERN BY ANALOGS INDICATES THE PRESENCE OF TEN OR MORE TRANSPORT SYSTEMS FOR AMINO ACIDS IN BRAIN CELLS
INHIBITION PATTERN BY ANALOGS INDICATES THE PRESENCE OF TEN OR MORE TRANSPORT SYSTEMS FOR AMINO ACIDS IN BRAIN CELLS
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类似物的抑制模式表明脑细胞中存在十个或更多氨基酸运输系统
DOI：
10.1111/j.1471-4159.1979.tb04554.x
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发表时间：
1979
影响因子：
4.7
通讯作者：
A. Lajtha
中科院分区：
文献类型：
--
作者：
H. Sershen;A. Lajtha
摘要--我们调查了存在于大脑中的氨基酸运输系统。在脑切片中测量细胞转运，并通过测量体内脑从血液中提取的短期(S 15)来估计毛细血管转运。用特异性摄取抑制类似物来区分不同的类别。氨基酸水平(接近生理)是这样的，主要是测量了“低亲和力”的运输。
Abstract— We surveyed the transport systems present in the brain for amino acids. Cellular transport was measured in brain slices, and capillary transport was estimated by measuring in vivo the short‐term (15 s) extraction by brain from the blood. Specific analog inhibition of uptake was used to distinguish the classes. Amino acid levels (close to physiological) were such that primarily the ‘low‐affinity’ transport was measured.