Perfluoroalkyl Acids in Maternal Serum and Indices of Fetal Growth: The Aarhus Birth Cohort.
Perfluoroalkyl Acids in Maternal Serum and Indices of Fetal Growth: The Aarhus Birth Cohort.
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孕产妇血清中的全氟烷基酸和胎儿生长指标：Aarhus出生队列。
DOI：
10.1289/ehp.1510046
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发表时间：
2016-06
影响因子：
10.4
通讯作者：
Henriksen TB
中科院分区：
文献类型：
--
作者：
Bach CC;Bech BH;Nohr EA;Olsen J;Matthiesen NB;Bonefeld-Jørgensen EC;Bossi R;Henriksen TB
先前的研究表明，宫内接触全氟辛烷磺酸（PFOS）或全氟辛酸盐（PFOA）与出生体重较低之间存在关联。然而，这些全氟烷基酸（PFAAs）在某种程度上已被其他鲜为人知的化合物所取代。我们调查了特定PFAAs与出生体重、出生长度和头围之间的关系。我们研究了来自奥胡斯出生队列（2008-2013）的1507名母亲和她们的孩子。在怀孕期间纳入未生育妇女，并在妊娠9至20周内测量16种PFAAs的血清水平（96%在13周内）。对于在bbb50 %的样品（7种化合物）中具有可量化值的化合物，我们报告了通过多变量线性回归确定的与出生体重、出生长度和头围的关联。血清全氟己烷磺酸、全氟庚烷磺酸和全氟辛烷磺酸浓度高于最低暴露四分位数的妇女的估计平均出生体重较低，但我们没有发现一致的单调剂量-反应模式。当人口限于足月分娩时，这些关联更强（n = 1426）。对于全氟辛烷磺酸，所有新生儿的最高四分位数与最低四分位数的出生体重估计值分别为-50 g （95% CI: -123, 23 g）和-62 g （95% CI: -126, 3 g）。对于其他PFAAs，相关性方向不一致，与出生体重没有明显的总体相关性。没有PFAAs与出生时的出生长度或头围相关。总体而言，我们没有发现PFAAs与出生体重或其他胎儿生长指标之间存在强烈或一致的关联，尽管在某些化合物的最低四分位数以上暴露的人群中，估计的平均出生体重较低。Bach CC, Bech BH, Nohr EA, Olsen J, Matthiesen NB, Bonefeld-Jørgensen EC, Bossi R, Henriksen TB。2016. 母亲血清中的全氟烷基酸和胎儿生长指标：奥胡斯出生队列。环境健康展望124:848-854；http://dx.doi.org/10.1289/ehp.1510046
Previous studies indicated an association between intrauterine exposure to perfluorooctane sulfonate (PFOS) or perfluorooctanoate (PFOA) and lower birth weight. However, these perfluoroalkyl acids (PFAAs) have to some extent been substituted by other compounds on which little is known. We investigated the association between specific PFAAs and birth weight, birth length, and head circumference at birth. We studied 1,507 mothers and their children from the Aarhus Birth Cohort (2008–2013). Nulliparous women were included during pregnancy, and serum levels of 16 PFAAs were measured between 9 and 20 completed gestational weeks (96% within 13 weeks). For compounds with quantifiable values in > 50% of samples (7 compounds), we report the associations with birth weight, birth length, and head circumference at birth determined by multivariable linear regression. Estimated mean birth weights were lower among women with serum perfluorohexane sulfonate, perfluoroheptane sulfonate, and PFOS concentrations above the lowest exposure quartile, but we found no consistent monotonic dose–response patterns. These associations were stronger when the population was restricted to term births (n = 1,426). For PFOS, the birth weight estimates for the highest versus lowest quartile were –50 g (95% CI: –123, 23 g) in all births and –62 g (95% CI: –126, 3 g) in term births. For the other PFAAs, the direction of the associations was inconsistent, and no overall association with birth weight was apparent. No PFAAs were associated with birth length or head circumference at birth. Overall, we did not find strong or consistent associations between PFAAs and birth weight or other indices of fetal growth, though estimated mean birth weights were lower among those with exposures above the lowest quartile for some compounds. Bach CC, Bech BH, Nohr EA, Olsen J, Matthiesen NB, Bonefeld-Jørgensen EC, Bossi R, Henriksen TB. 2016. Perfluoroalkyl acids in maternal serum and indices of fetal growth: the Aarhus Birth Cohort. Environ Health Perspect 124:848–854; http://dx.doi.org/10.1289/ehp.1510046