Neurobiological pathways linking socioeconomic position and health.
Neurobiological pathways linking socioeconomic position and health.
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DOI：
10.1097/psy.0b013e3181e1a23c
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发表时间：
2010-06
影响因子：
3.3
通讯作者：
Manuck SB
中科院分区：
文献类型：
--
作者：
Gianaros PJ;Manuck SB
在个人中，健康状况不佳的风险与社会经济地位(SEP)成反比。SEP影响健康的途径已从许多流行病学角度进行了研究。这些观点的核心观点是，社会经济健康差距是由于在一生中展开的嵌套的、递归的和累积的环境、社会、家庭、心理、行为和生理过程之间的相互作用而产生的。然而，关于社会经济健康差异的流行病学观点尚未正式整合神经药理学、分子遗传学和神经成像研究的新发现，这些研究表明SEP指标与脑神经传递、脑形态和脑功能模式有关，这些模式与慢性疾病和心理疾病的病因学有关。在这里，我们综述这些新发现，并考虑未来在这一领域的神经生物学研究如何提高我们对不同维度的SEP被大脑体现以影响一生健康的途径的理解。
Across individuals, risk for poor health varies inversely with socioeconomic position (SEP). The pathways by which SEP affects health have been viewed from many epidemiological perspectives. Central to these perspectives is the notion that socioeconomic health disparities arise from an interplay between nested, recursive, and cumulative environmental, social, familial, psychological, behavioral, and physiological processes that unfold over the life span. Epidemiological perspectives on socioeconomic health disparities, however, have not yet formally integrated emerging findings from neuropharmacological, molecular genetic, and neuroimaging studies demonstrating that indicators of SEP relate to patterns of brain neurotransmission, brain morphology, and brain functionality implicated in the etiology of chronic medical conditions and psychological disorders. Here, we survey these emerging findings and consider how future neurobiological studies in this area can enhance our understanding of the pathways by which different dimensions of SEP become embodied by the brain to influence health throughout life.