Alternating Delays Achieve Polarization Transfer (ADAPT) to heteronuclei in PHIP experiments
Alternating Delays Achieve Polarization Transfer (ADAPT) to heteronuclei in PHIP experiments
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DOI：
10.1016/j.jmr.2016.10.009
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发表时间：
2017-01-01
影响因子：
2.2
通讯作者：
Stevanato, Gabriele
中科院分区：
文献类型：
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作者：
Stevanato, Gabriele
提出了一种在有机小分子体系中通过仲氢诱导极化（PHIP）产生超极化C-13核的新方法：ADAPT（交替延迟实现极化转移）。该过程的理论基础进行了研究，在一些细节和实验的例子证明了该方法的可行性。可调参数的数量比大多数其他转换方案少。实现的理论异质极化是接近统一的任何检查磁等效制度。成功实施的脉冲序列的持续时间可以短于其他已建立的方法，从而减少可能的弛豫损失。该转换方案对B-1不均匀性具有鲁棒性，但对非共振RF照射更敏感。(C)2016 Elsevier Inc. All rights reserved.
A new methodology for producing hyperpolarized C-13 nuclei in small organic systems via parahydrogen induced polarization (PHIP) is proposed: ADAPT (Alternating Delays Achieve Polarization Transfer). The theoretical foundation of the process is investigated in some detail and experimental examples demonstrating the viability of the approach are provided as well. The number of adjustable parameters is fewer than most of other conversion schemes. The achieved theoretical heteronuclear polarization is close to unity for any examined magnetic equivalence regime. The duration of the pulse sequence, which was successfully implemented, can be shorter than other established methods reducing possible relaxation losses. The conversion scheme is robust to B-1 inhomogeneities, but more sensitive to off-resonance RF irradiation. (C) 2016 Elsevier Inc. All rights reserved.