A revised estimate of twin concordance in systemic lupus erythematosus.
A revised estimate of twin concordance in systemic lupus erythematosus.
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DOI：
10.1002/art.1780350310
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发表时间：
1992-03
影响因子：
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通讯作者：
D. Deapen;A. Escalante;Lisa Weinrib;D. Horwitz;Barbara Bachman;P. Roy-burman;A. Walker;T. Mack-T.-M
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文献类型：
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作者：
D. Deapen;A. Escalante;Lisa Weinrib;D. Horwitz;Barbara Bachman;P. Roy-burman;A. Walker;T. Mack-T.-M
目的根据一个小的临床系列和以前发表的病例报道，单卵双生子(MZ)与系统性红斑狼疮(SLE)的符合率高达69%。使用较大和较少偏差的样本，我们提供了对这一百分比的另一种估计。方法根据患者的自我报告和医生提供的信息，我们建立了双胞胎系统性红斑狼疮的登记。我们使用DNA指纹技术在这些双胞胎中的一个样本中验证了报告的合子。结果符合美国风湿病学会1982年修订的SLE诊断标准的107对双生子中，45对MZ和62对DZ的符合率分别为24%和2%。SLE患者的诊断标准和疾病症状的频率分布与其他已发表的SLE患者报告相似。15对自述MZ双胞胎和7对自称DZ双胞胎的DNA指纹图谱证实了合子。所有的个体都正确地预测了他们的合子。结论系统性红斑狼疮的MZ一致性与其他自身免疫性疾病的MZ一致性相似，远低于先前认为的水平。
OBJECTIVE Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage. METHODS We established a registry of twins with SLE, based upon self-reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins. RESULTS Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self-described MZ twins and 7 self-described DZ twins. All individuals had correctly predicted their zygosity. CONCLUSION MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed.