Effects of inhaled sympathomimetics on obstructive response to respiratory heat loss.
Effects of inhaled sympathomimetics on obstructive response to respiratory heat loss.
复制标题
吸入拟交感神经药对呼吸热损失阻塞反应的影响。
DOI：
10.1152/jappl.1982.52.5.1119
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
McFaddenJr,ER
中科院分区：
文献类型：
--
作者：
Rossing,TH;Weiss,JW;Breslin,FJ;IngramJr,RH;McFaddenJr,ER
为了研究吸入性拟交感神经药对气道冷却阻塞反应的影响，我们以随机盲法对6名无症状的特应性哮喘患者在用异丙肾上腺素或安慰剂气雾剂预处理后，在不同通气水平下用寒冷空气进行正常二氧化碳过度通气。在对照实验中，eucapnic过度通气产生了一个渐进的减少，在1秒用力呼气量的刺激反应的方式，在连续的挑战，随着通气水平的上升。Metaproterenol并没有产生全或无的封锁，而是一个平行移动的刺激-反应曲线，使其保护作用可以克服增加刺激。对呼吸热损失无影响。这些结果以定量的方式解释了为什么允许哮喘患者毫无困难地执行给定运动任务的治疗方案随着任务的热负荷或严重程度的增加而变得无效。
To investigate the influence of inhaled sympathomimetics on the obstructive response to airway cooling, we had six asymptomatic atopic asthmatics perform eucapnic hyperventilation with frigid air at various levels of ventilation after pretreatment with aerosols of metaproterenol or placebo in a random blind fashion. In control experiments, eucapnic hyperventilation produced a progressive decrease in 1-s forced expiratory volume in a stimulus-response fashion as the level of ventilation rose in successive challenges. Metaproterenol did not produce an all-or-none blockade, but rather a parallel shift in the stimulus-response curve so that its protective effects could be overcome by increasing the stimulus. There was no effect on respiratory heat loss. These results explain, in a quantitative fashion, why a treatment schedule that permits a person with asthma to perform a given exercise task without difficulty becomes ineffective as the thermal burden or severity of the task increases.