ALTERED SMALL-BOWEL MOTILITY IN IRRITABLE-BOWEL-SYNDROME IS CORRELATED WITH SYMPTOMS
ALTERED SMALL-BOWEL MOTILITY IN IRRITABLE-BOWEL-SYNDROME IS CORRELATED WITH SYMPTOMS
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DOI：
10.1016/0016-5085(87)90620-2
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发表时间：
1987-06-01
期刊：
影响因子：
29.4
通讯作者：
PHILLIPS, SF
中科院分区：
文献类型：
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作者：
KELLOW, JE;PHILLIPS, SF
肠易激综合征（IBS）的发病机制更多地与结肠运动障碍相关，而不是与小肠异常相关。为了寻找小肠异常，我们记录了 16 名 IBS 患者的超腔压。所有患者均主诉腹痛，腹泻（n = 8）或便秘（n = 8）也是突出症状。对 16 名年龄匹配的对照组进行了类似研究。观察结果包括白天和夜间的禁食记录以及对脂肪餐的反应。 IBS 中消化间期迁移肌电复合体的周期性较短 (p < 0.05)；这是因为腹泻患者的昼夜周期（77 .+-. 10 分钟）比便秘患者（118 .+-. 15 分钟）或对照组（113 .+-. 10 分钟，均 p < 0.05）要短得多。所有群体都表现出昼夜节律变化，夜间周期更加频繁。小肠运动活动的两种特定模式在 IBS .sbd 中更为常见。回肠推进波和空肠压力活动簇（与对照组相比，p < 0.05）。此外，当回肠蠕动有推进力时，IBS 通常会出现腹部痉挛性疼痛。空肠破裂有时也与腹部症状有关。我们得出的结论是，一些 IBS 患者的小肠运动发生了改变，并且某些运动模式与其症状相关。
The pathogenesis of irritable bowel syndrome (IBS) has been related more to dysmotility of the colon than to abnormalities of the small intestine. To look for small bowel abnormalities, we recorded ultraluminal pressures in 16 patients with IBS. All patients complained of abdominal pain, and diarrhea (n = 8) or constipation (n = 8) were also prominent symptoms. Comparable studies were performed on 16 age-matched controls. The observations include diurnal and nocturnal fasting recordings and the response to a fatty meal. Periodicities of the interdigestive migrating myoelectric complexes were shorter in IBS (p < 0.05); this was due to much shorter diurnal cycles in patients with diarrhea (77 .+-. 10 min) than those with constipation (118 .+-. 15 min) or controls (113 .+-. 10 min, both p < 0.05). All groups exhibited circadian changes, with nocturnal cycles being more frequent. Two specific patterns of small bowel motor activity were more common in IBS .sbd. ileal propulsive waves and clusters of jejunal pressure activity (both p < 0.05 compared to controls). Moreover, cramping abdominal pain was usually noted in IBS when ileal motility was propulsive; jejunal bursts were also sometimes associated with abdominal symptoms. We conclude that motility of the small intestine is modified in some patients with IBS and that certain motor patterns are related to their symptoms.