Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project
Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project
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DOI：
10.1038/ijo.2010.254
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发表时间：
2011-08-01
影响因子：
4.9
通讯作者：
Tjonneland, A.
中科院分区：
文献类型：
--
作者：
Halkjaer, J.;Olsen, A.;Tjonneland, A.
背景：由于蛋白质被认为比其他大量营养素更能促进产热和饱腹感，因此它可能在预防体重增加和保持体重方面具有有益的作用。目的：本研究的目的是评估膳食蛋白质的数量和类型与随后的体重和腰围(WC)变化之间的关系。方法：对参加欧洲癌症与营养前瞻性调查(EPIC)的5个国家的89432名男性和女性进行了平均6.5年的跟踪调查。通过性别和特定中心的多元回归分析，研究蛋白质或蛋白质亚类的摄入量(来自动物和植物)与体重(每年g)或WC(每年cm)的变化之间的关系。对其他基线饮食因素、基线人体测量学、人口统计学和生活方式因素以及随访时间进行了调整。我们使用随机效应荟萃分析来获得跨中心的综合估计。结果：较高的总蛋白和来自动物来源的蛋白质的摄入量与随后的体重增加有关，在女性中最明显，而且这种关联主要归因于来自红色和加工肉类和家禽的蛋白质，而不是来自鱼类和乳制品来源的蛋白质。在摄入植物蛋白和随后的体重变化之间没有总体联系。总蛋白摄入量或任何亚组与WC的变化之间没有明显的总体联系。这些关联在不同中心之间表现出一定的异质性，但估计值的合并仍然被认为是合理的。结论：在这项观察性研究中，没有发现高蛋白质摄入量与较低的体重或腰围增加相关。相比之下，来自动物性食物的蛋白质，特别是肉类和家禽，似乎与长期体重增加呈正相关。没有明确的腰围变化之间的联系。《国际肥胖杂志》(2011年)3511041113年；DOI：10.1038/ijo.2010.254；2010年12月7日在线发表
Background: As protein is considered to increase thermogenesis and satiety more than other macronutrients, it may have beneficial effects on prevention of weight gain and weight maintenance.Objective: The objective of this study is to assess the association between the amount and type of dietary protein, and subsequent changes in weight and waist circumference (WC).Methods: 89 432 men and women from five countries participating in European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a mean of 6.5 years. Associations between the intake of protein or subgroups of protein (from animal and plant sources) and changes in weight (g per year) or WC (cm per year) were investigated using gender and centre-specific multiple regression analyses. Adjustments were made for other baseline dietary factors, baseline anthropometrics, demographic and lifestyle factors and follow-up time. We used random effect meta-analyses to obtain pooled estimates across centres.Results: Higher intake of total protein, and protein from animal sources was associated with subsequent weight gain for both genders, strongest among women, and the association was mainly attributable to protein from red and processed meat and poultry rather than from fish and dairy sources. There was no overall association between intake of plant protein and subsequent changes in weight. No clear overall associations between intakes of total protein or any of the subgroups and changes in WC were present. The associations showed some heterogeneity between centres, but pooling of estimates was still considered justified.Conclusion: A high intake of protein was not found associated with lower weight or waist gain in this observational study. In contrast, protein from food items of animal origin, especially meat and poultry, seemed to be positively associated with long-term weight gain. There were no clear associations for waist changes. International Journal of Obesity (2011) 35, 1104-1113; doi:10.1038/ijo.2010.254; published online 7 December 2010