Effect of Circulating Omentin-1 on the Retinal Circulation in Patients With Type 2 Diabetes Mellitus
Effect of Circulating Omentin-1 on the Retinal Circulation in Patients With Type 2 Diabetes Mellitus
复制标题
DOI：
10.1167/iovs.17-22030
复制
发表时间：
2017-10-01
影响因子：
4.4
通讯作者：
Yoshida, Akitoshi
中科院分区：
文献类型：
--
作者：
Omae, Tsuneaki;Nagaoka, Taiji;Yoshida, Akitoshi
目的。旨在确定 2 型糖尿病患者视网膜循环参数与 omentin-1（一种由脂肪细胞产生的新型脂肪因子）血清浓度之间的显着相关性。方法。对 87 名患有 2 型糖尿病和早期糖尿病视网膜病变 (DR) 的患者进行了分析，并根据性别进一步分为两组。我们比较了激光多普勒测速仪测量的患者视网膜循环参数和血清 omentin-1 浓度。结果。血浆omentin-1浓度与视网膜血流量（RBF）呈正相关（r = 0.212；P = 0.048），主要与女性性别相关（r = 0.288；P = 0.06），与视网膜动脉血管阻力（RVR）呈负相关（r = -0.218；P = 0.043）。此外，血浆omentin-1浓度与血流速度呈适度但不显着的正相关。多元回归分析显示，血清omentin-1 水平对RVR 具有独立且负向的影响。结论。对于患有早期 DR 的 2 型糖尿病患者，尤其是女性患者，血浆 omentin-1 浓度的增加可能与 RBF 水平升高有关，这可能是通过血流速度升高而引起的，这值得进一步研究。
PURPOSE. To identify any significant correlations between retinal circulatory parameters and serum concentrations of omentin-1, a novel adipokine produced by adipocytes, in patients suffering from type 2 diabetes mellitus.METHODS. Eighty-seven patients suffering from type 2 diabetes and incipient diabetic retinopathy (DR) were analyzed and further divided into two groups according to sex. We compared the patients' retinal circulatory parameters measured with laser Doppler velocimetry and serum omentin-1 concentrations.RESULTS. The plasma omentin-1 concentrations were related positively to the retinal blood flow (RBF) (r = 0.212; P = 0.048) and primarily with female sex (r = 0.288; P = 0.06) and negatively to the retinal arterial vascular resistance (RVR) (r = -0.218; P = 0.043). Moreover, the plasma omentin-1 concentration was modestly but not significantly positively related to the blood velocity. Multiple regression analysis showed that the serum omentin-1 level contributed independently and negatively to the RVR.CONCLUSIONS. Increased concentrations of plasma omentin-1 might be linked to elevated RBF levels probably through elevated blood velocity in patients suffering from type 2 diabetes with incipient DR, especially in female patients, which warrants further investigation.