Photoactive Ru(II) Complexes With Dioxinophenanthroline Ligands Are Potent Cytotoxic Agents
Photoactive Ru(II) Complexes With Dioxinophenanthroline Ligands Are Potent Cytotoxic Agents
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DOI：
10.1021/ic5017164
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发表时间：
2014-10-06
影响因子：
4.6
通讯作者：
Glazer, Edith C.
中科院分区：
文献类型：
--
作者：
Hidayatullah, Achmad N.;Wachter, Erin;Glazer, Edith C.
两个含有2，3-dihydro-1，4-dioxino[2，3-f]-1，10-phenanthroline(DOP)配体的新型应变Ru(II)多吡啶配合物在~gt；400 nm光照射下选择性地发射甲基化配体。最好的化合物在光激活时对人类癌细胞的细胞毒性增加了1880倍，比众所周知的化疗药物顺铂强19倍。
Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.