Paternal and maternal components of the predisposition to preeclampsia.
Paternal and maternal components of the predisposition to preeclampsia.
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DOI：
10.1056/nejm200103223441201
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发表时间：
2001-03-22
影响因子：
158.5
通讯作者：
Varner, MW
中科院分区：
文献类型：
--
作者：
Esplin, MS;Fausett, MB;Varner, MW
背景：先兆子痫是一种遗传性的母体易感性。是否有一个父亲的组成部分，然而，是未知的。方法：我们使用的记录，犹他州人口数据库，以确定298名男子和237名妇女出生在犹他州之间的1947年和1957年的母亲在怀孕期间有先兆子痫。对于研究组中的每一名男性和女性，我们确定了两名匹配的、不相关的对照受试者，他们不是妊娠并发先兆子痫的产物。然后，我们确定了298名男性研究对象的947名儿童和237名女性研究对象的830名儿童，他们出生于1970年至1992年之间。这些儿童与对照组的后代（男性对照组的1973名后代和女性对照组的1658名后代）相匹配。确定与先兆子痫相关的因素，并使用逐步逻辑回归分析计算比值比。在母亲患有先兆子痫的男性中，（男性研究组），2.7%的后代（947人中有26人）出生于妊娠合并先兆子痫，而男性对照组中有1.3%的后代（1973人中有26人）。在女性研究组中，4.7%的妊娠（830人中的39人）并发先兆子痫，而女性对照组中为1.9%（1658人中的32人）。在对后代的出生年份、母亲产次和分娩时后代的胎龄进行调整后，母亲患有先兆子痫的成年人所生的孩子是妊娠并发先兆子痫的产物的优势比为2.1（95%置信区间，1.0至4.3; P=0.04），男性研究组和3.3（95%可信区间，1.5 ~ 7.5; P=0.004）。结论：与对照组相比，患有先兆子痫的男性和女性都更有可能生下患有先兆子痫的孩子。是妊娠并发先兆子痫的产物（N Engl J Med 2001;344：867-72.）版权所有（C）2001马萨诸塞州医学会。
Background: There is an inherited maternal predisposition to preeclampsia. Whether there is a paternal component, however, is not known.Methods: We used records of the Utah Population Database to identify 298 men and 237 women born in Utah between 1947 and 1957 whose mothers had had preeclampsia during their pregnancy. For each man and woman in the study group, we identified two matched, unrelated control subjects who were not the products of pregnancies complicated by preeclampsia. We then identified 947 children of the 298 male study subjects and 830 children of the 237 female study subjects who had been born between 1970 and 1992. These children were matched to offspring of the control subjects (1973 offspring of the male control group and 1658 offspring of the female control group). Factors associated with preeclampsia were identified, and odds ratios were calculated with the use of stepwise logistic-regression analysis.Results: In the group of men whose mothers had had preeclampsia (the male study group), 2.7 percent of the offspring (26 of 947) were born of pregnancies complicated by preeclampsia, as compared with 1.3 percent of the offspring (26 of 1973) in the male control group. In the female study group, 4.7 percent of the pregnancies (39 of 830) were complicated by preeclampsia, as compared with 1.9 percent (32 of 1658) in the female control group. After adjustment for the offspring's year of birth, maternal parity, and the offspring's gestational age at delivery, the odds ratio for an adult whose mother had had preeclampsia having a child who was the product of a pregnancy complicated by preeclampsia was 2.1 (95 percent confidence interval, 1.0 to 4.3; P=0.04) in the male study group and 3.3 (95 percent confidence interval, 1.5 to 7.5; P=0.004) in the female study group.Conclusions: Both men and women who were the product of a pregnancy complicated by preeclampsia were significantly more likely than control men and women to have a child who was the product of a pregnancy complicated by preeclampsia. (N Engl J Med 2001;344:867-72.) Copyright (C) 2001 Massachusetts Medical Society.