Increasing the resolution of the adult neurogenesis picture.
Increasing the resolution of the adult neurogenesis picture.
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DOI：
10.12703/p6-8
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gage FH
中科院分区：
文献类型：
--
作者：
Lacar B;Parylak SL;Vadodaria KC;Sarkar A;Gage FH
成年哺乳动物大脑中新神经元的诞生曾经被认为是不可能的现在是一个被广泛接受的现象，它发生在侧脑室和海马的脑室下区。本文综述了最近的工作，使我们对海马新生神经元的调节和功能的看法更加尖锐。研究领域包括（a）神经发生如何有助于行为模式分离，（B）模式分离如何受到新生神经元的特性和电路的影响，（c）神经发生如何调节和功能的背腹轴差异，以及（d）灵长类动物的成年神经发生，包括新的人类数据。这些目前的研究途径揭示了成人神经发生的新细节，并预示着我们在不久的将来可能会了解这一令人兴奋的现象。
The birth of new neurons in the adult mammalian brain—once thought impossible—is now a well-accepted phenomenon that takes place in the subventricular zone of the lateral ventricles and the hippocampus. This review focuses on the recent work that has sharpened our views of how hippocampal newborn neurons are regulated and function. Areas of study include (a) how neurogenesis contributes to behavioral pattern separation, (b) how pattern separation may be influenced by the properties and circuitry of newborn neurons, (c) differences along the dorsal-ventral axis of how neurogenesis is regulated and functions, and (d) adult neurogenesis in primates, including new human data. These current avenues of research reveal new details of adult neurogenesis and foreshadow what we may learn about this exciting phenomenon in the near future.