INCREASED ANTIRETROVIRAL ANTIBODY REACTIVITY IN SERA FROM A DEFINED POPULATION OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION WITH AUTOANTIBODIES AND CLINICAL MANIFESTATIONS
INCREASED ANTIRETROVIRAL ANTIBODY REACTIVITY IN SERA FROM A DEFINED POPULATION OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION WITH AUTOANTIBODIES AND CLINICAL MANIFESTATIONS
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DOI：
10.1002/art.1780370109
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发表时间：
1994-01-01
影响因子：
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通讯作者：
STURFELT, G
中科院分区：
文献类型：
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作者：
BLOMBERG, J;NIVED, O;STURFELT, G
Objective.逆转录病毒在小鼠系统性红斑狼疮（SLE）发病机制中的作用使我们在以人群为基础的SLE队列中研究抗逆转录病毒抗体。方法.使用全病毒和合成肽的免疫测定进行了72例SLE患者和88名对照组的血清。结果与整个狒狒内源性病毒的反应发生更频繁的SLE患者，并与抗RNP和抗Sm的存在。一些逆转录病毒env和gag肽，其中几个类似于U1小核RNP，在SLE患者中反应更强烈，它们的存在与盘状皮疹，血液病和其他症状相关。结论这些结果提供了间接证据参与逆转录病毒在人类SLE的发病机制，应进行进一步的研究，使用其他技术测量逆转录病毒的表达。
Objective. The implied role of retroviruses in the pathogenesis of murine systemic lupus erythematosus (SLE) led us to study antiretroviral antibodies in a population-based SLE cohort. Methods. Immunoassays using whole virus and synthetic peptides were performed on sera from 72 patients with SLE and 88 control subjects. Results. Reactions with whole baboon endogenous virus occurred more frequently in patients with SLE, and correlated with the presence of anti-RNP and anti-Sm. Some retroviral env and gag peptides, several of which were similar to U1 small nuclear RNP, reacted more strongly in patients with SLE, and their presence was correlated with discoid rash, hematologic disorder, and other symptoms. Conclusion. These results provide circumstantial evidence for involvement of retroviruses in the pathogenesis of human SLE; further studies should be carried out using other techniques for measurement of retroviral expression.