Prognostic and clinicopathological role of long non-coding RNA UCA1 in various carcinomas.
Prognostic and clinicopathological role of long non-coding RNA UCA1 in various carcinomas.
复制标题
长链非编码RNA UCA1在各种癌症中的预后和临床病理学作用
DOI：
10.18632/oncotarget.16059
复制
发表时间：
2017-04-25
期刊：
影响因子：
--
通讯作者：
Zhao S
中科院分区：
文献类型：
--
作者：
Wang X;Peng F;Cheng L;Yang G;Zhang D;Liu J;Chen X;Zhao S
尿路上皮癌相关蛋白1（UCA 1）作为一种致癌长链非编码RNA（LncRNA）在多种实体瘤中异常上调。大量研究表明，UCA 1过表达是癌症患者预后不良的指标。本研究旨在进一步探讨UCA 1在肿瘤预后中的作用及临床意义。通过在PubMed、Embase、科克伦图书馆和Web of Science数据库中进行系统检索，招募合格的研究。共纳入19/16项研究（1587/1291例癌症患者），通过计算风险比（HR）、比值比（OR）和置信区间（CI）评价UCA 1表达与恶性肿瘤总生存期（OS）和临床病理因素之间的关系。荟萃分析显示UCA 1过表达与癌症患者的非预期OS显著相关（合并HR = 1.85，95% CI 1.62-2.10，p < 0.001）。高水平的UCA 1与低级别癌症（合并OR = 2.74，95%CI 2.04-3.70，p < 0.001）和阳性淋巴转移（合并OR = 2.43，95%CI 1.72-3.41，p < 0.001）之间也呈显着负相关。总之，我们的研究表明，UCA 1与更先进的临床病理特征和不良预后相关，作为一种新的预测生物标志物的患者与各种肿瘤。
Urothelial cancer associated 1 (UCA1) as an oncogenic long non-coding RNA (LncRNA) was aberrantly upregulated in various solid tumors. Numerous studies have demonstrated overexpression of UCA1 is an unfavorable prognostic indicator in cancer patients. This study aimed to further explore the prognosis role and clinical significance of UCA1 in cancer. Eligible studies were recruited by a systematic search in PubMed, Embase, Cochrane Library and Web of Science databases. A total of 19/16 studies with 1587/1291 cancer patients were included to evaluate the association between UCA1 expression and overall survival (OS) and clinicopathological factors of malignancies by computing hazard ratio (HR), odds ratios (OR) and confidence interval (CI). The meta-analysis indicated overexpression of UCA1 was significantly correlated with unexpected OS in patients with cancer (pooled HR = 1.85, 95% CI 1.62–2.10, p < 0.001). There was also a significantly negative association between high level of UCA1 and poor grade cancer (pooled OR = 2.74, 95% CI 2.04–3.70, p < 0.001) and positive lymphatic metastasis (pooled OR = 2.43, 95% CI 1.72–3.41, p < 0.001). In conclusion, our study suggested that UCA1 was correlated with more advanced clinicopathological features and poor prognosis as a novel predictive biomarker of patients with various tumors.