Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis.
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis.
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DOI：
10.1182/blood.v76.4.655.655
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发表时间：
1990-08
期刊：
影响因子：
20.3
通讯作者：
S. Weitzman;L. Gordon
中科院分区：
文献类型：
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作者：
S. Weitzman;L. Gordon
我们已经回顾了一些数据，链接的活性氧产生的炎症吞噬细胞癌症的发展。虽然很明显，这些物质诱导的表型变化的特点，那些已知的致癌物质产生的，这些影响产生的确切机制需要进一步研究。在体外，吞噬细胞产生的氧化剂似乎是完全的致癌物，即可以引起肿瘤的发生和促进。然而，在体内，这些物质似乎通常作为肿瘤促进剂或辅致癌物，可能是因为高水平的内源性抗氧化剂防御。这表明，可能有更多的理由对人类癌症化学预防试验的积极结果持乐观态度，并为在当前和未来的试验中继续使用抗氧化剂和抗炎药物提供了进一步的理由。例如，国家癌症研究所的化学预防分支目前正在赞助七项校外人体功效干预试验，测试抗氧化剂β-胡萝卜素是否可以预防癌症。
We have reviewed some of the data that link the reactive oxygen species produced by inflammatory phagocytes to cancer development. While it is clear that these substances induce phenotypic changes characteristic of those produced by known carcinogens, the precise mechanisms by which these effects are produced require much further study. In vitro, it would appear that phagocyte-generated oxidants could be complete carcinogens, ie, could cause both tumor initiation and promotion. In vivo, however, these substances appear usually to function as tumor promoters or cocarcinogens perhaps because of high levels of endogenous antioxidant defenses. This suggests that there may be even more reason to be optimistic about the potential for positive results in cancer chemoprevention trials in humans, and provides further rationale for the continuing interest in the use of antioxidants and anti-inflammatory drugs in current and future trials. For example, the Chemoprevention Branch of the National Cancer Institute is currently sponsoring seven extramural human efficacy intervention trials testing whether the antioxidant beta carotene can prevent cancer.