Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages, and Disadvantages
Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages, and Disadvantages
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DOI：
10.1007/978-1-4939-7196-1_24
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Grove, Erik Lerkevang
中科院分区：
文献类型：
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作者：
Hvas, Anne-Mette;Grove, Erik Lerkevang
血小板功能测试主要用于血小板疾病的诊断工作。在过去的十年中，为了识别动脉血栓形成风险增加的患者，还出现了额外使用血小板功能测试来评估抗血小板治疗的效果。此外，为了减少出血的风险，越来越多的人在手术前使用血小板功能测试来衡量抗血小板治疗的残余效果。在有限的范围内，血小板功能试验也被用来评估高聚集性，作为抗血小板治疗之外的血栓前状态的潜在标志。血小板功能测试的这种多方面使用，以及应用范围更窄的更简单的护理点测试的开发，增加了血小板功能测试的使用，也促进了在高度专业化的实验室之外使用血小板功能测试。本章描述了分析前变量，在计划进行血小板功能测试时应考虑这些变量。同时介绍了目前应用最广泛的几种血小板功能检测方法，并对其临床应用价值和优缺点进行了讨论。
Platelet function tests are mainly used in the diagnostic work-up of platelet disorders. During the last decade, the additional use of platelet function tests to evaluate the effect of antiplatelet therapy has also emerged in an attempt to identify patients with an increased risk of arterial thrombosis. Furthermore, platelet function tests are increasingly used to measure residual effect of antiplatelet therapy prior to surgery with the aim of reducing the risk of bleeding. To a limited extend, platelet function tests are also used to evaluate hyperaggregability as a potential marker of a prothrombotic state outside the setting of antiplatelet therapy. This multifaceted use of platelet function tests and the development of simpler point-of-care tests with narrower application have increased the use of platelet function testing and also facilitated the use of platelet function tests outside the highly specialized laboratories. The present chapter describes the preanalytical variables, which should be taken into account when planning platelet function testing. Also, the most widely used platelet function tests are introduced, and their clinical utility and their relative advantages and disadvantages are discussed.