Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark.
Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark.
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由患者真皮成纤维细胞衍生的诱导多能干细胞分化而来的内皮细胞类似于葡萄酒胎记的血管畸形。
DOI：
10.1093/bjd/ljad330
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tan,Wenbin
中科院分区：
文献类型：
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作者：
Nguyen,Vi;Gao,Chao;Hochman,MarceloL;Kravitz,Jacob;Chen,ElliottH;Friedman,HaroldI;Wenceslau,CamillaF;Chen,Dongbao;Wang,Yunguan;Nelson,JStuart;Jegga,AnilG;Tan,Wenbin
损伤诱导的多能干细胞衍生的内皮细胞可以类似于葡萄酒胎记（PWB）的病理血管表型。我们的数据表明，多种途径，包括Hippo和Wnt，NFκB，TNF，MAPK和胆固醇代谢，失调。这些数据表明，可以开发新的治疗方法来靶向PWB治疗中的这种失调途径。
Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.