Metabolism and action of purine nucleoside analogs.
Metabolism and action of purine nucleoside analogs.
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DOI：
10.1016/0163-7258(91)90057-s
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发表时间：
1991
影响因子：
13.5
通讯作者：
W. Plunkett;P. Saunders
中科院分区：
文献类型：
--
作者：
W. Plunkett;P. Saunders
最近的研究发现了许多新的嘌呤核苷类似物，它们具有抗代谢作用。本文重点介绍了噻唑呋喃、3-去氮鸟苷、奈普诺菌素A、阿拉伯糖基腺嘌呤与腺苷脱氨酶抑制剂、阿拉伯糖基-2-氟腺嘌呤和2-氯-2‘-脱氧腺苷的联合用药的代谢和作用机制，这些药物目前正在进行临床试验或接近临床试验阶段。对这些化合物不同的代谢激活要求、独特的作用机制和不同的生物活性进行了表征和评估，以期应用于治疗。
Recent investigations have identified many new purine nucleoside analogs that act as antimetabolites. This article focuses on the metabolism and mechanisms of action of tiazofurin, 3-deazaguanosine, neplanocin A, arabinosyladenine in combination with inhibitors of adenosine deaminase, arabinosyl-2-fluoroadenine, and 2-chloro-2′-deoxyadenosine, drugs that are either currently being evaluated in clinical trials or are close to that stage. The diverse metabolic requirements for activation, unique mechanisms of action, and differential biological activities of these compounds are characterized and evaluated for prospective therapeutic application.