Expression of cadherin and CSF dissemination in malignant astrocytic tumors
Expression of cadherin and CSF dissemination in malignant astrocytic tumors
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DOI：
10.1007/s101430050030
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发表时间：
2000-03-01
影响因子：
2.8
通讯作者：
Suzuki, S
中科院分区：
文献类型：
--
作者：
Asano, K;Kubo, O;Suzuki, S
钙粘蛋白是 Ca2+ 依赖性细胞粘附分子，在多细胞生物的组织构建和形态发生中发挥重要作用。由于近年来有钙粘蛋白参与肿瘤转移的报道，我们对13例胶质母细胞瘤和9例间变性星形细胞瘤的原发性和复发性病变的石蜡包埋手术标本进行了E-钙粘蛋白和N-钙粘蛋白单克隆抗体的免疫染色。在肿瘤细胞中未检测到E-钙粘蛋白的表达。另一方面，在恶性星形细胞肿瘤细胞中观察到N-钙粘蛋白的表达，但在复发时N-钙粘蛋白阳性率趋于较低。胶质母细胞瘤组13例中，第II期复发时检测到N-cadherin表达降低。其中 9 名（81.8%）患者观察到脑脊液（CSF）播散和颅外转移。因此，我们试图通过统计分析其临床背景和N-cadherin阳性率。我们得出的结论是，复发时 N-钙粘蛋白表达的降低与恶性星形细胞肿瘤的播散相关。
Cadherins are Ca2+-dependent cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Because in recent years there have been reports of cadherin involvement in tumor metastasis, we conducted an immunostain for E-cadherin and N-cadherin monoclonal antibodies in paraffin-embedded surgical specimens of primary and recurrent lesions in 13 cases of glioblastoma and nine cases of anaplastic astrocytoma. No expression of E-cadherin was detected in the tumor cells. On the other hand, expression of N-cadherin was observed in malignant astrocytic tumor cells, but the N-cadherin positive rate tended to be less at the time of recurrence. Decreased expression of N-cadherin was detected at the time of recurrence in II of the 13 cases in the glioblastoma group. Cerebrospinal fluid (CSF) dissemination and extracranial metastasis were observed in nine (81.8%) of these ii patients. Therefore, we tried to analyze the clinical backgrounds and the N-cadherin positive rates by statistics. We concluded that decreased expression of N-cadherin at the time of recurrence correlates with dissemination in malignant astrocytic tumors.