Free-Water Imaging in White and Gray Matter in Parkinson's Disease
Free-Water Imaging in White and Gray Matter in Parkinson's Disease
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DOI：
10.3390/cells8080839
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发表时间：
2019-08-01
期刊：
影响因子：
6
通讯作者：
Aoki, Shigeki
中科院分区：
文献类型：
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作者：
Andica, Christina;Kamagata, Koji;Aoki, Shigeki
本研究旨在利用自由水（FW）成像区分帕金森病（PD）患者的白色物质（WM）和灰质（GM）中的神经炎症和神经元变性。对20名PD患者和20名健康个体使用基于轨迹的空间统计（TBSS）进行分析，结果显示FW成像指数（即，与DTI指数的变化相比，在更特定的WM区域，FW校正的各向异性分数（FA（T））降低，FW校正的平均、轴向和径向扩散率（分别为MDT、AD（T）和RDT）和FW体积分数（FW）增加。感兴趣区（ROI）分析进一步支持了这些发现，与对照组相比，PD患者在前WM区显示出显著较低的FA（T）和较高的MDT、AD（T）和RDT（神经元变性指数），以及在后WM区显示出较高的FW（神经炎症指数）。基于GM的空间统计（GBSS）分析结果显示，PD患者的MDT、AD（T）和FW显著高于对照组，而ROI分析显示MDT和FW显著增加，GM区域的AD（T）有增加的趋势，对应于Braak IV期。这些研究结果支持这一假设，即神经炎症先于神经元变性在PD，而WM的微结构改变之前的GM的变化。
This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson's disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FA(T)), increased FW-corrected mean, axial, and radial diffusivities (MDT, AD(T), and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with PD showed significantly lower FA(T) and higher MDT, AD(T), and RDT (indices of neuronal degeneration) in anterior WM areas as well as higher FW (index of neuroinflammation) in posterior WM areas compared with the controls. Results of GM-based spatial statistics (GBSS) analysis revealed that patients with PD had significantly higher MDT, AD(T), and FW than the controls, whereas ROI analysis showed significantly increased MDT and FW and a trend toward increased AD(T) in GM areas, corresponding to Braak stage IV. These findings support the hypothesis that neuroinflammation precedes neuronal degeneration in PD, whereas WM microstructural alterations precede changes in GM.