Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study.
Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study.
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DOI：
10.1093/aje/152.9.895
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发表时间：
2000-06
影响因子：
5
通讯作者：
W. Field;D. Steck;Brian J. Smith;C. Brus;E. L. Fisher;J. Neuberger;Charles E. PIatz;Robert A. Robinson;R. Woolson;Charles F. Lynch
中科院分区：
文献类型：
--
作者：
W. Field;D. Steck;Brian J. Smith;C. Brus;E. L. Fisher;J. Neuberger;Charles E. PIatz;Robert A. Robinson;R. Woolson;Charles F. Lynch
暴露于高浓度的氡子体（氡）会使地下矿工和实验暴露的实验动物患上肺癌。为了确定住宅氡暴露所造成的风险，作者于1993年至1997年在爱荷华州进行了一项基于人群的病例对照流行病学研究。研究对象为居住在目前住所至少20年的爱荷华州女性居民。最终的分析包括413例肺癌病例和614例年龄频率匹配的对照。对于病例诊断前5-19年（WLM(5-19)）或对照访谈时间前的暴露，计算每11个工作水平月的额外赔率。11 WLM（5-19）大约等于在此期间平均住宅氡暴露量为4 pCl/升（148 Bq/m3）。在调整了年龄、吸烟和受教育程度后，作者发现，在所有病例和活病例中，使用分类氡暴露估计分别为0.50（95%可信区间：0.004,1.81）和0.83（95%可信区间：0.11,3.34）的超额赔率。对于所有受试者和仅活体受试者的持续氡暴露估计，每11个WLM（5-19）的额外几率略低，分别为0.24（95%置信区间：-0.05,0.92）和0.49（95%置信区间：0.03,1.84）。观察到的风险估计表明，累积的环境氡暴露是一种重要的环境健康危害。
Exposure to high concentrations of radon progeny (radon) produces lung cancer in both underground miners and experimentally exposed laboratory animals. To determine the risk posed by residential radon exposure, the authors performed a population-based, case-control epidemiologic study in Iowa from 1993 to 1997. Subjects were female Iowa residents who had occupied their current home for at least 20 years. A total of 413 lung cancer cases and 614 age-frequency-matched controls were included in the final analysis. Excess odds were calculated per 11 working-level months for exposures that occurred 5-19 years (WLM(5-19)) prior to diagnosis for cases or prior to time of interview for controls. Eleven WLM(5-19) is approximately equal to an average residential radon exposure of 4 pCl/liter (148 Bq/m3) during this period. After adjustment for age, smoking, and education, the authors found excess odds of 0.50 (95% confidence interval: 0.004, 1.81) and 0.83 (95% percent confidence interval: 0.11, 3.34) using categorical radon exposure estimates for all cases and for live cases, respectively. Slightly lower excess odds of 0.24 (95 percent confidence interval: -0.05, 0.92) and 0.49 (95 percent confidence interval: 0.03, 1.84) per 11 WLM(5-19) were noted for continuous radon exposure estimates for all subjects and live subjects only. The observed risk estimates suggest that cumulative ambient radon exposure presents an important environmental health hazard.