CONTROLLED TRIAL OF FRUSEMIDE AS AN ANTIEPILEPTIC DRUG IN FOCAL EPILEPSY
CONTROLLED TRIAL OF FRUSEMIDE AS AN ANTIEPILEPTIC DRUG IN FOCAL EPILEPSY
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DOI：
10.1111/j.1365-2125.1976.tb04885.x
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发表时间：
1976-01-01
影响因子：
3.4
通讯作者：
RICHENS, A
中科院分区：
文献类型：
--
作者：
AHMAD, S;CLARKE, L;RICHENS, A
1 The antiepileptic activity of oral frusemide (120 mg daily) was compared with that of an identical placebo in a double-blind crossover trial in fourteen patients with severe focal epilepsy who were receiving long-term therapy with established antiepileptic drugs. 2 A statistically significant reduction in the frequency of focal fits was seen with the active drug. 3 Marked drowsiness occurred in three patients during frusemide therapy, causing their withdrawal from the trial. 4 A slight, but significant, rise in serum phenobarbitone concentrations was observed during frusemide therapy, but no change was seen in serum primidone or phenytoin concentrations. 5 Frusemide significantly lowered plasma sodium and potassium concentrations, and increased plasma bicarbonate.
