Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
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DOI：
10.1176/appi.ajp.160.9.1621
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发表时间：
2003-09-01
影响因子：
17.7
通讯作者：
Siever, LJ
中科院分区：
文献类型：
--
作者：
Hazlett, EA;Levine, J;Siever, LJ
目的：注意缺陷是分裂型人格障碍患者与精神分裂症患者共有的一种异常。本研究的目的是检测未用药的分裂型人格障碍患者惊恐眨眼反应的自动感觉运动门控和受控注意调节。方法：采用声学注意-脉搏前注意范式对18例分裂型人格障碍患者和16名健康人进行测试。参与者进行了一项选择性注意任务，包括呈现被注意的、被忽略的和作为前脉冲音调的新奇音调。结果：对照受试者在注意过程中表现出比忽略前脉冲更强的前脉冲抑制和前脉冲促进作用，表现出对惊恐眨眼反应的早期和晚期注意调制。结论：分裂型人格障碍受试者在控制注意加工方面存在缺陷，以惊恐眨眼反应的改变为指标，这与精神分裂症患者观察到的类似。
Objective: Attentional deficits have been identified as an abnormality that individuals with schizotypal personality disorder share with schizophrenia patients. The purpose of this study was to examine automatic sensorimotor gating and controlled attentional modulation of the startle eye blink response in unmedicated subjects with schizotypal personality disorder.Method: Eighteen unmedicated patients with schizotypal personality disorder and 16 healthy individuals were assessed in an acoustic attention-to-prepulse paradigm. The participants performed a selective attention task involving the presentation of attended, ignored, and novel tones that served as prepulse tones. Acoustic startle probes were presented at short and long lead intervals after the onset of tones and occasionally during the intertone interval.Results: The comparison subjects showed greater prepulse inhibition and prepulse facilitation during the attended than the ignored prepulses, demonstrating early and later attentional modulation of startle eye blink response. In contrast, the subjects with schizotypal personality disorder failed to show this pattern.Conclusions: Subjects with schizotypal personality disorder have deficits in controlled attentional processing, as indexed by modification of the startle eye blink response, that are similar to those observed in patients with schizophrenia.