Lipase-mediated desymmetrization of glycerol with aromatic and aliphatic anhydrides
Lipase-mediated desymmetrization of glycerol with aromatic and aliphatic anhydrides
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DOI：
10.1016/j.tetasy.2004.09.033
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发表时间：
2004-11-15
影响因子：
--
通讯作者：
Ubukata, M
中科院分区：
文献类型：
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作者：
Batovska, DI;Tsubota, S;Ubukata, M
研究了手性酶L-2（Candidaanastritica）在1，4-二氧六环中催化甘油与脂肪族和芳香族酸酐的酯化反应。所有芳香族单酰基甘油（MAG）作为（R）-对映异构体产生，而脂肪族MAG作为外消旋混合物或（S）-对映异构体获得。取代的芳环，链长，和存在的共轭双键的酰基供体部分上的对映体的选择性以及效率的酶的影响进行了研究。(C)2004 Elsevier Ltd.保留所有权利。
Chirazyme L-2 (Candida antarctica) catalyzed esterification of glycerol with aromatic and aliphatic anhydrides in 1,4-dioxane is described. All the aromatic monoacylglycerols (MAGs) were produced as (R)-enantiomers, while aliphatic MAGs were obtained either as racemic mixtures or the (S)-enantiomers. The influence of substituted aromatic rings, chain length, and presence of a conjugated double bond in the acyl donor moiety on the enantiotopic selectivity as well as the efficiency of the enzyme was studied. (C) 2004 Elsevier Ltd. All rights reserved.