CD146 gene expression in clear cell renal cell carcinoma: a potential marker for prediction of early recurrence after nephrectomy
CD146 gene expression in clear cell renal cell carcinoma: a potential marker for prediction of early recurrence after nephrectomy
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DOI：
10.1007/s11255-012-0255-4
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发表时间：
2012-12-01
影响因子：
2
通讯作者：
Pu, Chun
中科院分区：
文献类型：
--
作者：
Feng, Gang;Fang, Fang;Pu, Chun
目的探讨CD 146基因表达对预测肾切除术后早期复发的价值。结果转移性cRCC中CD 146表达的平均值为100%，而转移性cRCC中CD 146表达的平均值为100%，差异有统计学意义（P < 0.05）。（0.0438 +/- 0.0024）显著高于局限性cRCC患者（0.0374 +/- 0.0012，P = 0.018）或对照组（0.0344 +/- 0.0010，P = 0.001）。在局限性cRCC患者中，复发患者的CD 146表达显著高于无复发患者（P = 0.029）。单因素分析显示CD 146与早期复发相关。无复发生存曲线显示，CD 146高表达患者的复发率显著高于低表达患者（P = 0.018）。结论CD 146基因表达可作为早期预测复发的指标，并可作为辅助治疗的依据。
Objectives To investigate whether CD146 gene expression could provide useful information to predict early recurrence after nephrectomy.Methods This study included 84 patients with clear cell renal cell carcinoma (cRCC), and 44 subjects without tumor were used as controls. Quantitative RTPCR was used to measure the CD146 gene expression.Results The mean value of CD146 expression in patients with metastatic cRCC (0.0438 +/- 0.0024) was significantly higher than in those with localized cRCC (0.0374 +/- 0.0012, P = 0.018) or in controls (0.0344 +/- 0.0010, P = 0.001). Of patients with localized cRCC, those with recurrence had a significantly higher CD146 expression than those without recurrence (P = 0.029). The univariate analysis showed that CD146 was associated with early recurrence. The recurrence-free survival curve indicated that patients with a high CD146 expression had a significantly higher recurrence rate than those with a low CD146 expression (P = 0.018).Conclusions CD146 gene expression can be useful for predicting early recurrence and stratifying the patients into risk groups for possible adjuvant treatment.