A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: Implication for tumorigenesis
A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: Implication for tumorigenesis
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DOI：
10.1158/1078-0432.ccr-06-1633
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发表时间：
2007-02-15
影响因子：
11.5
通讯作者：
Cheah, Peh Yean
中科院分区：
文献类型：
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作者：
Hong, Yi;Ho, Kok Sun;Cheah, Peh Yean
目的：常染色体显性遗传的家族性腺瘤性息肉病（FAP）和遗传性非息肉病性结直肠癌的致病基因已得到很好的表征。然而，另有10%至15%的早发性结直肠癌（CRC）的遗传成分尚不清楚。在这项研究中，我们使用微阵列技术系统地寻找在早发性结直肠癌中差异表达的基因。实验设计：非FAP或非遗传性非息肉病性结直肠癌的年轻患者和健康对照者年龄-（
Purpose: The causative genes for autosomal dominantly inherited familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer have been well characterized. There is, however, another 10% to 15% of early onset colorectal cancers (CRC) in which the genetic components are unclear. In this study, we used microarray technology to systematically search for differentially expressed genes in early onset CRC.Experimental Design: Young patients with non - FAP or non - hereditary nonpolyposis colorectal cancer, and healthy controls were age- (