A passionate kiss, then run: exocytosis and recycling of IgG by FcRn
A passionate kiss, then run: exocytosis and recycling of IgG by FcRn
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DOI：
10.1016/j.tcb.2004.11.004
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发表时间：
2005-01-01
影响因子：
19
通讯作者：
Blumberg, RS
中科院分区：
文献类型：
--
作者：
Lencer, WI;Blumberg, RS
MHC-I类-样Fc γ受体FcRn从大多数细胞中清除免疫球蛋白（IG）G，并将其双向转运穿过上皮屏障以影响全身和粘膜免疫。最近的研究表明，FcRn通过将IgG从分选内体再循环到细胞表面来拯救IgG免于细胞内溶酶体降解。大多数回收囊泡以经典的胞吐模式与质膜完全融合。类似于突触连接处神经递质释放的过程，其他囊泡仅部分融合，释放FcRn-IgG复合物以在延长的时间段内以3-4秒的周期混合到质膜中。
The MHC-class-I-like Fcgamma receptor FcRn recycles immunoglobulin (Ig)G from most cells and transports it bidirectionally across epithelial barriers to affect systemic and mucosal immunity. Recent studies have shown that FcRn rescues IgG from intracellular lysosomal degradation by recycling it from the sorting endosome to the cell surface. Most recycling vesicles fuse completely with the plasma membrane in a classical pattern of exocytosis. Similar to the process seen for neurotransmitter release at synaptic junctions, other vesicles fuse only partially, releasing FcRn-IgG complexes to mix into the plasma membrane in cycles of 3-4 s over prolonged periods of time.