MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells
MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells
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DOI：
10.1016/j.febslet.2013.05.054
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发表时间：
2013-07-11
期刊：
影响因子：
3.5
通讯作者：
Tang, Hua
中科院分区：
文献类型：
--
作者：
Liu, Shang;Zhang, Peipei;Tang, Hua
我们的研究证实了microRNA-7 （miR-7）在宫颈癌中的功能。在宫颈癌细胞系HeLa和C-33A中过表达miR-7可抑制细胞活力，促进细胞凋亡，而抑制miR-7则相反。此外，一种致癌基因，X-linked inhibitor of apoptosis protein （XIAP）被确定为miR-7的新靶点，并且XIAP的异位表达挽救了miR-7在HeLa和C-33A细胞中诱导的作用。这些结果表明，miR-7靶向并下调癌基因XIAP，调节miR-7对HeLa和C-33A细胞凋亡和恶性行为的影响。(C) 2013年由Elsevier B.V.代表欧洲生化学会联合会出版。
Our study demonstrated the functions of microRNA-7 (miR-7) in cervical cancer. The overexpression of miR-7 in the cervical cancer cell lines HeLa and C-33A suppressed cell viability and promoted cell apoptosis, whereas the inhibition of miR-7 had opposite effects. Furthermore, an oncogene, X-linked inhibitor of apoptosis protein (XIAP), was identified as a new target of miR-7, and the ectopic expression of XIAP rescued the effects induced by miR-7 in HeLa and C-33A cells. These results indicate that miR-7 targeted and downregulated the oncogene XIAP to regulate the effect of miR-7 on apoptosis and malignant behaviors of HeLa and C-33A cells. (C) 2013 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.