Long-term release of monomers from modern dental-composite materials
Long-term release of monomers from modern dental-composite materials
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DOI：
10.1111/j.1600-0722.2008.00594.x
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发表时间：
2009-02-01
影响因子：
1.9
通讯作者：
Kuemmerer, Klaus
中科院分区：
文献类型：
--
作者：
Polydorou, Olga;Koenig, Armin;Kuemmerer, Klaus
复合材料中单体的洗脱影响口腔修复体的生物相容性。本研究的目的是考察不同固化时间(0、20、40和80 S)和不同存放时间(固化后24小时、7天、28天和1年)后，单体[双酚A甲基丙烯酸缩水甘油酯(BISGMA)、三甘醇二甲基丙烯酸酯(TEGDMA)、氨基甲酸酯二甲基丙烯酸酯(UDMA)和双酚A(BPA)]从两种光固化材料(纳米杂化材料和有机陶瓷)和化学固化复合材料中的洗脱情况。每个样本都储存在1毫升的75%乙醇中。在24小时、7天、28天和1年后更新该培养液。采用LC-MS/MS对乙醇样品进行了分析。纳米杂化和化学固化复合材料的单体释放量明显高于球磨机的释放量。固化时间对单体的释放有显著影响。对于纳米杂化材料，随着固化时间的延长，单体的释放量减少。对于发酵剂而言，80 S的腌制可以导致较高的单体释放度。不同单体的储存效果不同。尽管TEGDMA的洗脱量在储存28d和1年后显著减少，但在所分析的每个储存时间点，即使在1年后，也有类似数量的双GMA被释放。目前的研究表明，与其他材料相比，有机硅材料释放的单体数量非常少。
The elution of monomers from composite materials influences the biocompatibility of dental restorations. The purpose of the present study was to investigate the elution of monomers [bisphenol A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), urethane dimethacrylate (UDMA), and bisphenol A (BPA)] from two light-cured materials (nanohybrid and ormocer) and from a chemically cured composite material, after different curing times (0, 20, 40 and 80 s) and different storage periods (24 h, 7 d, 28 d, and 1 yr after curing). Each specimen was stored in 1 ml of 75% ethanol. This medium was renewed after 24 h, 7 d, 28 d, and 1 yr. The ethanol samples were analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS). The amount of monomers released from the nanohybrid and the chemically cured composite was significantly higher than released from the ormocer. The curing time exerted a significant effect on the release of monomers. For the nanohybrid, less monomer was released after increasing the curing time. For the ormocer, 80 s of curing resulted in a higher degree of monomer release. The effect of storage differed between the monomers. Although the elution of TEGDMA was significantly decreased after storage for 28 d and 1 yr, a similar amount of BisGMA was released at each storage time-point analyzed, even after 1 yr. The present study showed that ormocer released a very small amount of monomers compared with the other materials.