A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines
A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines
复制标题
DOI：
10.1128/iai.65.3.1109-1113.1997
复制
发表时间：
1997-03-01
影响因子：
3.1
通讯作者：
Kaslow, DC
中科院分区：
文献类型：
--
作者：
Duffy, PE;Kaslow, DC
Pfs 28的抗体阻断恶性疟原虫传播，当与Pfs 25的抗体组合时，在阻断传播中提供协同作用。Pfs 28和Pfs 25是免疫原性的，具有有限的抗原多样性，并且在结构上相似并且在10号染色体上遗传连锁。Pfs28可能被证明是Pfs25在有效传播阻断疫苗中的有用补充。
Antibodies to Pfs28 block Plasmodium falciparum transmission and when combined with antibodies to Pfs25 provide synergy in blocking transmission. Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine.