Bone lining cells: structure and function.
Bone lining cells: structure and function.
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发表时间：
1989-09
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通讯作者：
S. Miller;L. Saint-Georges;B. Bowman;Webster S. S. Jee-Webster-S.-S.-Jee-2245644906
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作者：
S. Miller;L. Saint-Georges;B. Bowman;Webster S. S. Jee-Webster-S.-S.-Jee-2245644906
骨衬细胞（BLC）覆盖不活跃（非重塑）的骨表面，在成人骨骼中尤其明显。 BLC 薄薄地延伸到骨表面，具有扁平或略呈卵圆形的细胞核，通过间隙连接与其他 BLC 连接，并将细胞突起送入表面小管。 BLC 可被诱导增殖并分化为成骨细胞，并且可能代表“确定的”成骨前体细胞的来源。 BLC 和骨内膜组织的其他细胞可能是骨髓基质系统的组成部分，并且可能通过控制诱导微环境在造血中具有重要功能。由于骨重塑的激活发生在不活跃的骨表面上，因此 BLC 可能参与启动骨吸收和骨重塑的激活信号的传播。证据还表明，BLC 对于维持骨液以及骨液和间质液室之间的离子通量以实现矿物质稳态非常重要。
Bone lining cells (BLC's) cover inactive (nonremodeling) bone surfaces, particularly evident in the adult skeleton. BLC's are thinly extended over bone surfaces, have flat or slightly ovoid nuclei, connect to other BLC's via gap junctions, and send cell processes into surface canaliculi. BLC's can be induced to proliferate and differentiate into osteogenic cells and may represent a source of "determined" osteogenic precursors. BLC's and other cells of the endosteal tissues may be an integral part of the marrow stromal system and have important functions in hematopoiesis, perhaps by controlling the inductive microenvironment. Because activation of bone remodeling occurs on inactive bone surfaces, BLC's may be involved in the propagation of the activation signal that initiates bone resorption and bone remodeling. Evidence also suggests that BLC's are important in the maintenance of the bone fluids and the fluxes of ions between the bone fluid and interstitial fluid compartments for mineral homeostasis.