'Arm-reaching' neurons in the parietal area V6A of the macaque monkey
'Arm-reaching' neurons in the parietal area V6A of the macaque monkey
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DOI：
10.1046/j.0953-816x.2001.01618.x
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发表时间：
2001-06-01
影响因子：
3.4
通讯作者：
Galletti, C
中科院分区：
文献类型：
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作者：
Fattori, P;Gamberini, M;Galletti, C
在以前的实验中，我们发现猕猴上级顶叶V6 A区的几个细胞被手臂的小而刻板的运动激活（C。Galletti，P. Fattori，D. F. Kutz和P.P. Battaglini，Eur J. Neurosci.，1997，9，410）。这种行为不是由视网膜信息，也不是由手臂的体感输入。我们现在想研究V6 A神经元是否受到旨在到达视觉目标或位于视野外的目标的有目的运动的调制。当猴子在黑暗中进行延迟到达任务期间进行手臂运动时，收集V6 A神经元活动。这项任务要求动物在近个人空间中伸出手去抓一个视觉目标，然后把手放回身体。对55个V6 A神经元进行的神经元活动的定量分析表明：（i）绝大多数神经元（71%）在执行手臂运动时受到显著调制，（ii）30%的神经元在准备伸手时受到显著调制;以及（iii）在执行和准备伸手过程中的调节发生在没有任何视觉反馈的情况下，并且不是由于眼睛运动。V6 A到达相关神经元可能有助于引导手到达目标，无论是否有视觉反馈。
In previous experiments we have found that several cells of area V6A in the macaque superior parietal lobule were activated by small and stereotyped movements of the arms (C. Galletti, P. Fattori, D. F. Kutz & P. P. Battaglini, Eur J. Neurosci., 1997, 9, 410). This behaviour was not accounted for by retinal information, nor by somatosensory inputs from the arms. We now want to investigate whether V6A neurons are modulated by purposeful movements aimed at reaching visual targets or targets located outside the field of view. V6A neuronal activity was collected while monkeys performed arm movements during an instructed-delay reaching task in darkness. The task required the animal to reach out for a visual target in the peripersonal space and to bring the hand back to its body. Quantitative analysis of neuronal activity carried out on 55 V6A neurons showed that: (i) the great majority of neurons (71%) was significantly modulated during the execution of arm movements; (ii) 30% of neurons were significantly modulated during preparation of reaching; and (iii) modulations during both execution and preparation of reaching occurred in the absence of any visual feedback and were not due to eye movements. V6A reach-related neurons could be useful in guiding the hand to reach its target with or without visual feedback.