Circadian Timekeeping and Multiple Timescale Neuroendocrine Rhythms
Circadian Timekeeping and Multiple Timescale Neuroendocrine Rhythms
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DOI：
10.1111/j.1365-2826.2010.01955.x
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Bonnefont, X.
中科院分区：
文献类型：
--
作者：
Bonnefont, X.
垂体前叶分泌的激素调节生殖、身体生长和新陈代谢等主要功能。它们的作用效率高度依赖于它们在血流中释放的时间曲线。这篇综述总结了最近的证据表明，昼夜节律基因的步伐，我们的日常节奏也可能有助于调节垂体脉动，即使在非24小时的范围。分子昼夜节律振荡器和内分泌节律之间的相互关系进行了讨论，在长期的文献中，已被认为是位于视交叉上核的中央昼夜节律起搏器的参与。其他参数，表明生物钟基因外的视交叉上核的作用也提出，特别强调垂体内分泌细胞和下丘脑神经内分泌神经元，直接起搏垂体分泌率。
The hormones secreted by the anterior pituitary gland regulate major functions such as reproduction, as well as body growth and metabolism. Their efficiency of action highly depends on their temporal profile of release in the blood stream. This review summarises the recent evidence suggesting that the circadian clock genes that pace our daily rhythms may also contribute to the regulation of pituitary pulsatility, even in the non 24-h range. This inter-relation between molecular circadian oscillators and endocrine rhythmicities is discussed in light of the longstanding literature that has considered the involvement of the central circadian pacemaker located within the suprachiasmatic nuclei. Other arguments that suggest a role for circadian clock genes outside the suprachiasmatic nuclei are also presented, with a special emphasis on endocrine pituitary cells and hypothalamic neuroendocrine neurones that directly pace pituitary secretion rates.