INFLUENCE OF BLOODFLOW ON THE ABSORPTION OF THEOPHYLLINE FROM THE JEJUNUM OF THE RAT
INFLUENCE OF BLOODFLOW ON THE ABSORPTION OF THEOPHYLLINE FROM THE JEJUNUM OF THE RAT
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DOI：
10.1023/a:1016374508542
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发表时间：
1984-01-01
影响因子：
3.7
通讯作者：
DEBLAEY, CJ
中科院分区：
文献类型：
--
作者：
SCHURGERS, N;DEBLAEY, CJ
研究了茶碱在空肠的吸收受空肠血流的影响。通过将供体血液输注到颈静脉或将异丙肾上腺素或左丙肾上腺素输注到股静脉来改变全身血压，并通过收集肠段的静脉流出物来测量通过所研究的段的血流量。当血流量高于约0.40 µl/min/cm时，流量/流量比降低，并提出在此流量以上，肠上皮提供茶碱吸收的限速步骤。当血流保持较低的时间较长，茶碱的流量下降。计算吸收部位血流量为研究节段总血流量的18%。
The influence of the jejunal bloodflow on the absorption of theophylline was investigated. The bloodflow through a segment under investigation was varied by changing the systemic blood pressure by means of a donor blood infusion into the jugular vein or by an infusion of isoprenaline or levarterenol into a femoral vein, and was measured by collecting the venous outflow from the intestinal segment. Above a bloodflow of approximately 0.40 µl/min/cm the flux/ flow ratio is reduced, and it is proposed that above this flow the intestinal epithelium provides the rate limiting step in the absorption of theophylline. When the bloodflow was held low for a prolonged time, the flux of theophylline decreased. The absorptive site bloodflow was calculated to be 18 % of the total bloodflow through the segment under investigation.