Evolution of the spectrin-based membrane skeleton
Evolution of the spectrin-based membrane skeleton
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DOI：
10.1016/j.tracli.2010.06.008
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发表时间：
2010-09-01
影响因子：
1.7
通讯作者：
Baines, A. J.
中科院分区：
文献类型：
--
作者：
Baines, A. J.
一组四种蛋白质血影蛋白。锚蛋白4 1和内收蛋白是与后生动物一起进化的。这些膜-细胞骨架蛋白与细胞膜的胞质面上的肌动蛋白交联，并将各种跨膜蛋白连接到细胞骨架上。分析了这些蛋白质的进化。基因组学表明血影蛋白是最早出现的，因为领鞭毛虫Monosiga brevicohs的基因组含有α基因，β和β H血影蛋白这种生物体代表了一种游离的-许多后生动物被认为已经分化，这表明血影蛋白在动物进化之前出现简单的动物，如板形动物Trichoplax adherens还含有4.1的可识别的前体，锚蛋白和内收蛋白。但它们可能不能结合血影蛋白锚蛋白和内收蛋白似乎随着组织的出现而获得了血影蛋白结合活性，因为它们似乎在所有的cumetazoa中具有基本相同的结构域结构4 1最近随着脊椎动物的出现而适应于结合血影蛋白并促进其与锚蛋白的相互作用一个简单的假设是，加速是先决条件对于动物生命，血影蛋白与锚蛋白和内收蛋白的相互作用是主要组织进化所必需的。随着脊椎动物的出现，动物的体型增大，4 - 1获得了血影蛋白-肌动蛋白结合活性。血影蛋白/锚蛋白/内收蛋白/4 - 1复合物代表了支撑动物生命的显著系统。在动物进化的不同时期，它已经适应了许多不同的功能（C）2010由Elsevier Masson SAS出版
A group of four proteins spectrin. ankyrin. 4 1 and adductin evolved with the metazoa These membrane-cytoskeletal proteins cross-link actin on the cytoplasmic face of plasma membranes and link a variety of transmembrane proteins to the cytoskeleton In this paper. the evolution of these proteins is analysed Genomics indicate that spectrin was the first to appear, since the genome of the choanoflagellate Monosiga brevicohs contains genes for alpha, beta and beta H spectrin This organism represents a lineage of free-living and colonial protisis from Much the metazoa ate considered to have diverged This indicates that spectrin emerged in evolution before the animals Simple animals such as the placozoan Trichoplax adherens also contain recognizable precursors of 4.1, ankyrin and adducin. but these could probably not bind spectrin Ankyrin and adducin seem to have acquired spectrin-binding activity with the appearance of tissues since they appear to have largely the same domain structure in all cumetazoa 4 1 was adapted more recently, with the emergence of the vertebrates, to bind spectrin and promote its Interaction with ankyrin A simple hypothesis is that sped on was prerequisite (but not sufficient) for animal life, that spectrin interaction with ankyrin and adducin was requited for evolution of major tissues. and that 4 1 acquired a spectrin-actin binding activity as animal size increased with the appearance of vertebrates The spectrin/ankyrin/adducin/4 1 complex represents a remarkable system that underpins animal life. It has been adapted to many different functions at different times during animal evolution (C) 2010 Published by Elsevier Masson SAS