Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth.
Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth.
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DOI：
10.1055/s-0038-1635109
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发表时间：
2018-08
影响因子：
2
通讯作者：
Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
中科院分区：
文献类型：
--
作者：
Clark EAS;Weiner SJ;Rouse DJ;Mercer BM;Reddy UM;Iams JD;Wapner RJ;Sorokin Y;Malone FD;O'Sullivan MJ;Peaceman AM;Hankins GDV;Dudley DJ;Caritis SN;Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
评估硫酸镁（MgSO 4）暴露和候选基因多态性与早产后不良神经发育结局的相关性。我们进行了巢式病例对照分析的一项随机试验，产妇硫酸镁预期早产前预防脑性瘫痪（CP）。病例为1岁时死亡的儿童或2岁时神经发育异常的幸存者。对照组为种族和性别匹配的幸存者，神经发育正常。我们分析了炎症、凝血和血管调节通路中的45个候选基因多态性及其与1）精神发育迟滞、2）智力迟滞、3）CP和4）死亡/CP联合结局的相关性。进行逻辑回归分析，以母亲种族和儿童性别为条件，并调整治疗组，出生时胎龄和母亲教育。共分析了406例受试者，其中211例病例和195例对照。精神延迟：最强的相关性是IL 6 R（rs 4601580），其中每个次要等位基因的额外拷贝与精神发育迟滞风险增加相关（aOR 3.3; 95%CI 1.7-6.5）。智力发育迟缓：IL 6 R中的三个SNPs与智力发育迟缓相关。IL 6、MBL 2和F7中的其他SNP显示了MgSO 4处理的相互作用。CP：TLR 4（rs 4986790）与CP相关（aOR 5.5; 95%CI，1.1-26.9）。IL 1 β和PAI 1的SNP显示MgSO 4处理的交互作用。死亡/CP：F7和NOS 3中的SNP与死亡/CP的联合结局相关。候选基因多态性与早产后死亡和不良神经发育结局相关。MgSO 4可消除某些基因座的基因型关联。候选基因多态性与早产儿的死亡和不良神经发育结局相关; MgSO 4可能会消除某些遗传位点的这种关联。
To evaluate the association of magnesium sulfate (MgSO4) exposure and candidate gene polymorphisms with adverse neurodevelopmental outcomes following preterm birth. We performed a nested case-control analysis of a randomized trial of maternal MgSO4 before anticipated preterm birth for prevention of cerebral palsy (CP). Cases were children who died by 1 year of life or were survivors with abnormal neurodevelopment at age 2 years. Controls were race- and sex-matched survivors with normal neurodevelopment. We analyzed 45 candidate gene polymorphisms in inflammation, coagulation and vascular regulation pathways and their association with 1) psychomotor delay, 2) mental delay, 3) CP and 4) combined outcome of death/CP. Logistic regression analyses, conditional on maternal race and child sex, and adjusted for treatment group, gestational age at birth and maternal education, were performed. Four hundred and six subjects, 211 cases and 195 controls, were analyzed. Psychomotor delay: The strongest association was for IL6R (rs 4601580) in which each additional copy of the minor allele was associated with an increased risk of psychomotor delay (aOR 3.3; 95%CI 1.7-6.5). Mental delay: Three SNPs in IL6R were associated with mental developmental delay. Additional SNPs in IL6, MBL2, and F7 showed MgSO4 treatment interaction. CP: TLR4 (rs4986790) was associated with CP (aOR 5.5; 95%CI, 1.1-26.9). SNPs in IL1β and PAI1 showed MgSO4 treatment interaction. Death/CP: SNPs in F7 and NOS3 were associated with the combined outcome of death/CP. Candidate gene polymorphisms are associated with death and adverse neurodevelopmental outcomes following preterm birth. MgSO4 may abrogate this genotype association for some loci. Candidate gene polymorphisms are associated with death and adverse neurodevelopmental outcomes in children born preterm; MgSO4 may abrogate this association for some genetic loci.
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影响因子：
37.8
作者：
Orsini F;Villa P;Parrella S;Zangari R;Zanier ER;Gesuete R;Stravalaci M;Fumagalli S;Ottria R;Reina JJ;Paladini A;Micotti E;Ribeiro-Viana R;Rojo J;Pavlov VI;Stahl GL;Bernardi A;Gobbi M;De Simoni MG
通讯作者：
De Simoni MG
影响因子：
3.8
作者：
Li, J;Ji, L
通讯作者：
Ji, L
影响因子：
120.7
作者：
Crowther, CA;Hiller, JE;Haslam, RR
通讯作者：
Haslam, RR
影响因子：
8
作者：
Gibson, Catherine S.;MacLennan, Alastair H.;Nelson, Karin B.
通讯作者：
Nelson, Karin B.
影响因子：
3
作者：
Marret, Stephane;Doyle, Lex W.;Middleton, Philippa
通讯作者：
Middleton, Philippa