Diversity and complexity in the pyramidal tract projectome.
Diversity and complexity in the pyramidal tract projectome.
复制标题
锥体束投影组的多样性和复杂性。
DOI：
10.1038/nrn3469-c2
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Shepherd,GordonMG
中科院分区：
文献类型：
--
作者：
Shepherd,GordonMG
在他们对我的评论的回应中（皮质纹状体连接及其在疾病中的作用。Nature Rev. Neurosci. 14, 278–291 (2013)）1，Smith 等人（皮质纹状体和中皮质多巴胺系统：物种差异重要吗？Nature Rev. Neurosci. http://dx.doi.org/10.1038/nrn3469-c1 (2013)） 2 突出了引人入胜的主题并提出了有趣的新想法和示意图，我希望这将有助于激发这些重要领域的更多研究和讨论。在这个有限的篇幅中，我重点讨论锥体束（PT）相关的问题。对于与灵长类动物相关的端脑内 (IT) 与 PT 问题，读者可以参考 Pasquereau 和 Turner 的关键研究 3，并且可以在我的评论和参考文献 1 中寻求术语澄清。PT 系统遵循基本的哺乳动物计划，具有许多进化专门化 4、5、6、7、8、9。Smith 等人。图 2 提出了一种区别，其中单个 PT 轴突的脊髓上分支在大鼠中广泛存在，但在灵长类动物中大多不存在。毫无疑问，PT 分支在哺乳动物之间存在某种差异，并且所提出的组织可能是正确的。如下文所述，我想知道该提案的各个方面是否可以被视为暂定，但新的表述无疑为进一步调查提供了明确的起点。
In their response to my Review (Corticostriatal connectivity and its role in disease. Nature Rev. Neurosci. 14, 278–291 (2013)) 1, Smith et al.(Corticostriatal and mesocortical dopamine systems: do species differences matter? Nature Rev. Neurosci. http://dx. doi. org/10.1038/nrn3469-c1 (2013)) 2 highlight fascinating topics and present intriguing new ideas and schematics, which I hope will help to stimulate more research and discussion in these important areas. In this limited space, I focus on the pyramidal tract (PT)-related issues. For primate-related intratelencephalic (IT) versus PT issues, readers are referred to Pasquereau and Turner's pivotal study 3, and terminological clarifications may be sought in my Review and references therein 1.The PT system follows a basic mammalian plan, with many evolutionary specializations 4, 5, 6, 7, 8, 9. Smith et al. 2 propose a distinction in which the supraspinal branching of single PT axons is extensive in rats but mostly absent in primates. Undoubtedly, PT branching is somehow differentiated across mammals, and the proposed organization may be correct. As touched on below, I wonder whether aspects of this proposal may be considered tentative, but certainly the new formulation offers well-defined starting points for further investigation.