Polyamine pools in HIV-infected cells.
Polyamine pools in HIV-infected cells.
复制标题
HIV感染细胞中的多胺库。
DOI:
10.1097/00042560-199802010-00001
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发表时间:
1998
期刊:
影响因子:
--
通讯作者:
Secrist3rd,JA
中科院分区:
文献类型:
--
作者:
White,EL;Rose,LM;Allan,PW;BuckheitJr,RW;Shannon,WM;Secrist3rd,JA
: The polyamines putrescine, spermine, and spermidine, present in all living cells, have been implicated in the replication of some herpesviruses and retroviruses, and elevated levels of these polyamines have been found in the lymphocytes of patients infected with HIV-1. We have examined the effect of HIV-1 infection on polyamine pools in cell culture. HIV-1 did not significantly affect the polyamine pools in CEM cells. Consistent with this observation, inhibitors of the two key enzymes of this pathway, ornithine decarboxylase and S-adenosylmethionine decarboxylase, did not prevent viral-induced cytopathic effects (CPE) in this cell line. Our results indicate that inhibitors of this pathway will not be therapeutically useful in the treatment of AIDS.
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影响因子:
3.3
作者:
H. Elo
通讯作者:
H. Elo
影响因子:
5
作者:
White,EL;Arnett,G;Secrist3rd,JA;Shannon,WM
通讯作者:
Shannon,WM
影响因子:
2
作者:
Porter,CW;Sufrin,JR
通讯作者:
Sufrin,JR
DOI:
--
发表时间:
1983
期刊:
影响因子:
--
作者:
J. Seely;A. Pegg
通讯作者:
A. Pegg
DOI:
--
发表时间:
1985
期刊:
Biochemical and Biophysical Research Communications - BBRC
影响因子:
--
作者:
R. Khomutov;T. Hyvönen;Eija Karvonen;L. Kauppinen;T. Paalanen;L. Paulin;T. Eloranta;R. Pajula;Leif C. Andersson;H. Pösö
通讯作者:
H. Pösö