Polymerization-induced shrinkage in giant butadienic lipid vesicles
Polymerization-induced shrinkage in giant butadienic lipid vesicles
复制标题
聚合诱导的巨大丁二烯脂质囊泡的收缩
作者：
M. Dvolaitzky;M. Guedeau;L. Léger
一种新的丁二烯类脂质二甲双[2（十四溴二烯- 2,4 -二烯基）氧乙基]溴化铵被用来形成巨大的囊泡。在紫外线照射下，观察到这些囊泡的形态发生了惊人的变化：整体收缩，同时膜增厚或皱缩（取决于照射条件）。收缩动力学与聚合动力学完全不同（慢得多）（通过二烯共轭双键在262 nm处的吸收消失来监测）。这表明了一个两步过程：由快速聚合引起的收缩，随后是囊泡内部分水的缓慢排出。
A new butadienic lipid, dimethylbis [2 (tetradeca-2, 4-dienoyl) oxyethyl] ammonium bromide, has been used toform giant vesicles. Under UV irradiation, a spectacular change in the morphology of these vesicles is observed: a global shrinkage, along with a thickening or crumpling of the membrane (depending upon the conditions of irradiation). The kinetics of the shrinkage are totally different (much slower) than those of the polymerization (monitored by the disappearance of the absorption due to the conjugated double bonds of the diene at 262 nm). This is indicative of a two-step process: the shrinkage resulting from rapid polymerization followed by slow expulsion of part of the water inside the vesicles.