Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase
Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase
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DOI：
10.1016/s0741-8329(97)00108-0
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发表时间：
1998-02-01
期刊：
影响因子：
2.3
通讯作者：
Zetterman, RK
中科院分区：
文献类型：
--
作者：
Donohue, TM;Drey, ML;Zetterman, RK
我们比较了急性和慢性乙醇给药对大鼠肝脏酪氨酸转氨酶（TAT）活性和合成的影响。在急性实验中，食物喂养的大鼠接受单剂量的乙醇（6克/公斤体重）或盐水。在长期研究中，大鼠配对喂养含有乙醇（占卡路里 36%）或等热量麦芽糖糊精的液体饮食 6-8 周。在急性喂食乙醇的大鼠中，TAT 合成的相对速率比盐水处理的对照组高两倍多。在接受长期乙醇给药的大鼠中，TAT活性和合成率与配对喂养对照组相同，但两组中的这两个参数与急性给予急性乙醇的动物相同。这些发现表明，虽然急性乙醇施用与刺激 TAT 合成相关，但长期乙醇施用则不然。数据表明乙醇本身并不直接诱导TAT。相反，酶合成受到一种或多种内源性次级效应器的调节，其产生受到急性或慢性乙醇喂养的不同影响。 (C) 1998 爱思唯尔科学公司。
We compared the effects of acute and chronic ethanol administration on the activity and synthesis of tyrosine aminotransferase (TAT) in rat liver. In acute experiments, chow-fed rats received a single dose of either ethanol (6 g/kg body wt.) or saline. In chronic studies, rats were pair fed liquid diets containing either ethanol (36 % of calories) or isocaloric maltose-dextrin for 6-8 weeks. In rats acutely fed ethanol, the relative rate of TAT synthesis was more than twofold higher than in saline-treated controls. In rats subjected to chronic ethanol administration, both the TAT activity and synthesis rate were the same as in pair-fed controls, but both these parameters in the two groups were equal to those in animals given acute ethanol acutely. These findings indicate that whereas acute ethanol administration was associated with a stimulation of TAT synthesis, long-term ethanol administration was not. The data suggest that ethanol itself does not directly induce TAT. Rather, enzyme synthesis is regulated by one or more endogenous secondary effector(s) whose production is influenced differently by acute or chronic ethanol feeding. (C) 1998 Elsevier Science Inc.