H2S induces a suspended animation-like state in mice
H2S induces a suspended animation-like state in mice
复制标题
DOI：
10.1126/science.1108581
复制
发表时间：
2005-04-22
期刊：
影响因子：
56.9
通讯作者：
Roth, MB
中科院分区：
文献类型：
--
作者：
Blackstone, E;Morrison, M;Roth, MB
尽管环境温度发生变化，哺乳动物通常保持其核心体温（CBT）。这一规范包括暂停的动画般的状态，如冬眠，麻木，夏眠。这些状态的特征都是代谢率显著下降，随后失去恒温控制，动物的CBT接近环境。我们报告说，硫化氢可以诱导一个悬浮的animation样的状态在非冬眠的物种，家鼠（小家鼠）。这种状态很容易逆转，似乎不会伤害动物。这表明了诱导悬浮的类动画状态用于医学应用的可能性。
Mammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation–like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.