Prostaglandin A1 and E1 inhibit the plating efficiency and proliferation of murine melanoma cells (Cloudman S-91) in soft agar.
Prostaglandin A1 and E1 inhibit the plating efficiency and proliferation of murine melanoma cells (Cloudman S-91) in soft agar.
复制标题
前列腺素 A1 和 E1 抑制软琼脂中鼠黑色素瘤细胞 (Cloudman S-91) 的铺板效率和增殖。
DOI：
10.1016/0006-291x(82)91360-2
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
MeyskensJr,FL
中科院分区：
文献类型：
--
作者：
Bregman,MD;Sander,D;MeyskensJr,FL
PGE1和PGE1以剂量依赖的方式降低Cloudman S-91小鼠黑色素瘤细胞的接种效率，抑制细胞增殖，通过软琼脂集落形成来评价它们的作用。PgF_2-α对cAMP和cGMP水平无明显影响，但对cAMP和cGMP水平的升高作用与PGF_1相当。这一数据表明，抑制Cloudman S-91小鼠黑色素瘤细胞的生长是通过非环核苷酸机制实现的。
PGA1and PGE1reduced the plating efficiency and inhibited proliferation of Cloudman S-91 murine melanoma cells in a dose dependent manner, as assessed by their effects on colony formation in soft agar. PGF2αdid not reduce plating efficiency but was as effective as PGA1in raising cAMP and cGMP levels. This data suggests that the inhibition of Cloudman S-91 murine melanoma cell growth occurs via a non-cyclic nucleotide mechanism.