RETINAL GANGLION-CELLS IN ALZHEIMERS-DISEASE AND AGING
RETINAL GANGLION-CELLS IN ALZHEIMERS-DISEASE AND AGING
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DOI：
10.1002/ana.410330305
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发表时间：
1993-03-01
影响因子：
11.2
通讯作者：
DRUCKER, DN
中科院分区：
文献类型：
--
作者：
CURCIO, CA;DRUCKER, DN
视神经和视网膜神经节细胞（GC）变性是阿尔茨海默病（AD）患者报告的视觉功能差的可能解释。我们研究了GC损失是否可以归因于AD与对照组相比，通过测量GC的空间密度（细胞/mm 2）与以前用于分析年轻正常视网膜的GC分布的方法。将来自4名尸检证实的患有AD的严重痴呆患者和4名年龄和性别匹配的对照受试者（两组年龄均为66-86岁）的视网膜制备为未染色的整体标本。没有证据表明AD患者在中心43度视力范围内GC丧失。与年轻人的视网膜相比，AD和对照组的中央11度视力的GC密度均降低了四分之一，鼻侧视网膜楔中的GC密度也降低了四分之一。这种损失可能导致老年人视觉功能的缺陷，无论他们是否患有痴呆症。
Optic nerve and retinal ganglion cell (GC) degeneration are possible explanations for the poor visual function reported in patients with Alzheimer's disease (AD). We investigated whether GC loss could be attributed to AD compared with control subjects by measuring the spatial density of GC (cells/mm2) with methods previously used to analyze the GC distribution of young normal retinas. Retinas from 4 autopsy-confirmed, severely demented patients with AD and 4 age- and sex-matched control subjects (ages, 66-86 yr for both groups) without history of dementing or ocular disease were prepared as unstained whole mounts. There was no evidence for loss of GC within the central 43 degrees of vision in patients with AD. The density of GC subserving the central 11 degrees of vision was reduced by one-fourth in both AD and control eyes compared with retinas from young adults, as was GC density in a wedge of nasal retina. This loss may contribute to deficits in visual function found in aged individuals, whether or not they have dementia.