SAMPLING DESIGNS FOR STEREOLOGY
SAMPLING DESIGNS FOR STEREOLOGY
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DOI：
10.1111/j.1365-2818.1981.tb01265.x
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发表时间：
1981-01-01
影响因子：
2
通讯作者：
WEIBEL, ER
中科院分区：
文献类型：
--
作者：
CRUZORIVE, LM;WEIBEL, ER
本文的目的是提出必要的采样技术，用于估计固体不透明试样中定义的全局参数（例如，给定肝脏中线粒体的总体积、给定肺中的总毛细血管表面积等）。样品的几何形状通常表明在不同放大率下的多级或级联采样设计，其中一个级别的对象相位成为下一个级别的参考相位。最终的参数，然后估计为产品的中间比率与体积的标本，这是独立估计。每一个水平都可以被看作是一个独立的抽样设计;一个给定的体视学项目可以根据一个或多个这些设计来规划。这一发展融合了体视学采样的实践经验和最新理论进展，以及以前为不同目的开发的众所周知的采样技术。
The purpose of this paper is to propose the necessary sampling techniques for estimating a global parameter defined in a solid opaque specimen (e.g., the total volume of mitochondria in a given liver, the total capillary surface area in a given lung, etc.). The geometry of the specimen often suggests a multi-level or cascade sampling design at different magnifications, whereby the object phase at one level becomes the reference phase in the next level. The final parameter is then estimated as the product of the intermediate ratios with the volume of the specimen, which is estimated independently. Each level can be regarded as an independent sampling design; a given stereological project may be planned in terms of one or more of these designs. This development is a blend of practical experience and recent theoretical advances on sampling for stereology with well-known sampling techniques previously developed with different purposes in mind.