Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene.
Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene.
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伯基特淋巴瘤是由获得 MYC 易位和 ETV6 抑癌基因丢失后的淋巴浆细胞淋巴瘤引起的。
DOI：
10.5858/arpa.2011-0429-cr
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发表时间：
2013
影响因子：
4.6
通讯作者：
Ling Zhang
中科院分区：
文献类型：
--
作者：
D. Peker;Brian C. Quigley;Dahui Qin;P. Papenhausen;Ling Zhang
淋巴浆细胞性淋巴瘤是一种成熟的B细胞淋巴瘤，具有不同的浆细胞分化，表现为无痛的临床病程。其转化为高级别B细胞淋巴瘤的情况可能并不常见。虽然获得MYC易位可导致低级别淋巴瘤转变为弥漫性大B细胞淋巴瘤、Burkitt淋巴瘤或B淋巴母细胞性白血病，但据我们所知，后两种转化在淋巴浆细胞性淋巴瘤中尚未得到很好的报道。我们报告一位70岁女性，有9年淋巴浆细胞性淋巴瘤/Waldenström巨球蛋白血症病史，表现为左颈肿块迅速增大及全血细胞减少，诊断为Burkitt淋巴瘤并广泛累及骨髓。一系列的组织病理学、分子和细胞遗传学检测证实了一种细胞遗传学进化，包括t(8；14)(q24；q32)/MYC-IgH和来自两个不同淋巴瘤的完全相同的克隆性B细胞基因重排，证实4期侵袭性Burkitt淋巴瘤起源于淋巴浆细胞淋巴瘤。
Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with variable plasmacytic differentiation that displays an indolent clinical course. Its transformation to a high-grade B-cell lymphoma may occur uncommonly. Although acquisition of a MYC translocation could result in transformation of a low-grade lymphoma into diffuse large B-cell lymphoma, Burkitt lymphoma, or B-lymphoblastic leukemia, to our knowledge the latter 2 transformations have not been well documented in lymphoplasmacytic lymphoma. We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma.