The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity.
The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity.
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癌症转移中lncRNA和microRNA之间的串扰：协调上皮间质可塑性
DOI：
10.18632/oncotarget.13957
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发表时间：
2017-02-14
期刊：
影响因子：
--
通讯作者：
Liang XH
中科院分区：
文献类型：
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作者：
Cao MX;Jiang YP;Tang YL;Liang XH
非编码RNA（ncRNA）已被证明与基因调控密切相关，包括众所周知的microRNA（miRNAs），以及最近公认的长非编码RNA（lncRNA）。目前的证据表明，lncRNA可以与miRNA相互作用，并且这些相互作用通过调节关键事件特别是上皮-间质转化（EMT）在癌症转移中起关键作用。本文综述了目前发现的lncRNA-miRNA串扰的类型，并讨论了它们对上皮-间质可塑性的影响和临床转移的意义。
Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelial-mesenchymal transition (EMT). This review summarizes the types of lncRNA-miRNA crosstalk identified to-date and discusses their influence on the epithelial-mesenchymal plasticity and clinical metastatic implication.