Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.
Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.
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内在的前脑唤醒动力学控制感觉刺激编码。
DOI：
10.1101/2023.10.04.560900
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Liu,Xiao
中科院分区：
文献类型：
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作者：
Yang,Yifan;Leopold,DavidA;Duyn,JeffH;Sipe,GraysonO;Liu,Xiao
感觉刺激的神经编码受大脑内部回路动态的影响。最近的研究表明，休息时的大脑表现出广泛的、协调的活动，这些活动以准周期尖峰级联的形式在多秒的时间尺度上进行。在这里，我们证明这些内在动力学在视觉刺激呈现期间持续存在，并显着影响视觉皮层中特征编码的功效。在被动观看期间，视觉刺激的感觉编码是由几秒钟内演变的准周期性级联循环决定的。在此周期中，高效率编码发生在峰值唤醒状态期间，与海马纹波及时交替，海马纹波在低唤醒状态下最常见。然而，在主动运动期间，这些唤醒动态被消除：大脑仍处于视觉编码效率保持高且不存在涟漪的状态。我们假设大脑在清醒、被动观看过程中观察到的动态反映了交替的外感受感觉采样和内部记忆功能的适应性循环。
The neural encoding of sensory stimuli is subject to the brain’s internal circuit dynamics. Recent work has demonstrated that the resting brain exhibits widespread, coordinated activity that plays out over multisecond timescales in the form of quasi-periodic spiking cascades. Here we demonstrate that these intrinsic dynamics persist during the presentation of visual stimuli and markedly influence the efficacy of feature encoding in the visual cortex. During periods of passive viewing, the sensory encoding of visual stimuli was determined by quasi-periodic cascade cycle evolving over several seconds. During this cycle, high efficiency encoding occurred during peak arousal states, alternating in time with hippocampal ripples, which were most frequent in low arousal states. However, during bouts of active locomotion, these arousal dynamics were abolished: the brain remained in a state in which visual coding efficiency remained high and ripples were absent. We hypothesize that the brain’s observed dynamics during awake, passive viewing reflect an adaptive cycle of alternating exteroceptive sensory sampling and internal mnemonic function.