INFLUENCE OF RESTRICTED FOOD-INTAKE ON BROWN ADIPOSE-TISSUE FUNCTION IN GENETICALLY-OBESE MICE (GENOTYPE, OB OB)
INFLUENCE OF RESTRICTED FOOD-INTAKE ON BROWN ADIPOSE-TISSUE FUNCTION IN GENETICALLY-OBESE MICE (GENOTYPE, OB OB)
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DOI：
10.1016/0304-4165(85)90083-2
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
SUTTON, CM
中科院分区：
文献类型：
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作者：
BATT, RAL;TYLER, DD;SUTTON, CM
测量了遗传性肥胖小鼠和野生型同胞棕色脂肪组织中线粒体的细胞色素c氧化酶活性和GDP结合能力，以估计该组织的产热能力。与野生型动物相比，自由采食的肥胖动物的结合能力降低。限制肥胖动物的喂养以限制其体重，导致组织结合能力大幅增加，这大于随意喂养或限制饮食的野生型动物。肥胖小鼠棕色脂肪组织线粒体结合能力的降低似乎是随意喂养的结果，因此不是肥胖的原因。肥胖动物的限制喂养也纠正了它们在低环境温度下的特征性体温过低。在肥胖动物的棕色脂肪组织的产热能力的大幅度增加，诱导有限的喂养，可能是他们的体温调节的重要改善。在肥胖、低温和通过约束在野生型动物中诱导的低温之间发现了密切的相似性。显然，肥胖引起的姿势改变，导致身体热量损失增加，可能是肥胖性体温过低的重要原因。肥胖动物的体重比野生型动物增加得更多，这表明它们棕色脂肪组织的高产热能力并不能调节它们的卡路里摄入。
Measurements were made of cytochrome c oxidase activity and the GDP-binding capacity of mitochondria in brown adipose tissue of genetically obese mice and wild-type siblings, to estimate the thermogenic capacity of the tissue. The binding capacity was decrased in ad libitum fed obese animals compared with wild-type animals. Limited feeding of obese animals to restrict their body wt caused a large increase in the binding capacity of the tissue, which was greater than that in wild-type animals fed either ad libitum or on a limited diet. The decreased binding capacity of brown adipose tissue mitochondria in obese mice appears to be a consequence of ad libitum feeding and therefore not a cause of the obesity. Limit feeding of obese animals also corrected their characteristic hypothermia at low ambient temperature. The large increase in the thermogenic capacity of brown adipose tissue in obese animals, induced by limited feeding, may account for the vital improvement of their thermoregulation. Close similarities were found between obesity hypothermia and hypothermia induced in wild-type animals by restraint. Apparently, changes in posture caused by obesity, resulting in increased loss of body heat, may be improtant in the development of obesity hypothermia. Obese animals fed less than wild-type gained more wt than wild-type animals, indicating that the high thermogenic capacity of their brown adipose tissue did not function to regulate their calorie intake.