An Animal Model of Hepatotoxicity Associated with Halothane Anesthesia
An Animal Model of Hepatotoxicity Associated with Halothane Anesthesia
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氟烷麻醉相关肝毒性动物模型
DOI：
10.1097/00000542-197612000-00005
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发表时间：
1976
期刊：
影响因子：
8.8
通讯作者：
B. R. Brown
中科院分区：
文献类型：
--
作者：
I. Spies;B. R. Brown
在大鼠中，在用单剂量的多氯联苯Aroclor 1254预处理后，单次暴露于1%氟烷的氧气溶液中，可诱导肝坏死。肝脏病变是centrilohular和多灶性的，形态学上类似的报告发生在man. In体外孵育14 C-氟烷表明，增强的共价结合氟烷代谢产物的肝微粒体大分子，特别是脂质，多氯联苯1254预处理后。在这些动物中未观察到微粒体不饱和脂肪酸的脂质过氧化。
Hepatic necrosis was induced in rats by a single exposure to 1 per cent halothane in oxygen following pretreatment with a single dose of Aroclor 1254, a polychlorinated biphenyl. The hepatic lesion was centrilohular and multifocal, and morphologically similar to that reported to occur in man. In-vitro incubation with 14C-halothaane indicated an enhanced covalent binding of halothane metabolites to hepatic microsomal macromolecules, particularly lipids, following Aroclor 1254 pretreatment. Lipoperoxidation of microsomal unsaturated fatty acids was not observed with these animals.